Title	Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine
ID	3515061
External ID	110000332
Author
Published Date	Oct. 23, 2024, 6 a.m.
Summary	Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine Perspective Therapeutics, Inc. Perspective Therapeutics, Inc. Wed, Oct 23, 2024, 4
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Sentiment	Negative: 0.00819 Neutral: 0.73548 Positive: 0.25633
Relevance	0.00935

Content ID	1846765
Key	f7352b7b-d458-42ab-b2b5-ef47ea16d4f7
Content	Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine Perspective Therapeutics, Inc. Perspective Therapeutics, Inc. Wed, Oct 23, 2024, 4:00 AM 10 min read In This Article: CATX -5.65% SEATTLE, Oct. 23, 2024 (GLOBE NEWSWIRE) -- Perspective Therapeutics, Inc. (“Perspective” or the “Company”) (NYSE AMERICAN: CATX), a radiopharmaceutical company that is pioneering advanced treatment applications for cancers throughout the body, today announced six updates on the Company’s radiopharmaceutical programs being presented at the 37th Annual Congress of the European Association of Nuclear Medicine ("EANM") held in Hamburg, Germany, from October 19-23, 2024. “The preclinical studies and first-in-human imaging data presented with [ 212 Pb]Pb-PSV359, our novel cyclic peptide targeting fibroblast activation protein-alpha, are very encouraging and validate the potential of this radiopharmaceutical in treating a variety of epithelial-derived cancers,” said Thijs Spoor, Perspective’s CEO. “We also note the valuable contributions from our scientists, collaborators and independent investigators to advancing the development of our potential new medicines, including updated safety and efficacy observations of [ 212 Pb]Pb-VMT-α-NET.” [ 212 Pb]Pb-PSV359 Presentation One : Preclinical evaluation and first-in-human imaging of [ 203/212 Pb]Pb-PSV359, a novel cyclic peptide targeting fibroblast activation protein-alpha (FAP) Summary : Lead-212 ( 212 Pb; alpha-particle therapy) and lead-203 ( 203 Pb; SPECT imaging) are an elementally identical isotope pair for image-guided, targeted-alpha-particle therapy. High-throughput screening of approximately 3 billion amino acid sequences and affinity maturation identified PSV359, a cyclic peptide targeting human fibroblast activation protein ("hFAP"), which is commonly overexpressed in a variety of cancers. The purpose of this study was to conduct the in vitro and in vivo evaluation of [ 203 Pb /212 Pb]Pb-PSV359, and present first-in-human SPECT/CT imaging of [ 203 Pb]Pb-PSV359. The findings of the study demonstrated that [ 212 Pb]Pb- PSV359 exhibits strong binding affinity (Kd=1.8 nM, Ki=0.4 nM) and selectivity for hFAP. Preclinical biodistribution and imaging studies revealed strong tumor uptake of [ 212 Pb]Pb- PSV359 with fast renal clearance and low background in off-target tissues. Furthermore, strong anti-tumor efficacy of [ 212 Pb]Pb-PSV359 was found in both HT1080-hFAP (FAP on cancer cells) and U87MG (FAP in stromal tissues) xenograft models. First-in-human SPECT/CT images of [ 203 Pb]Pb-PSV359 from an independent investigator revealed strong tumor uptake, fast clearance through the renal system, low accumulation in normal organs, and long tumor retention in all three patients with FAP expressing cancers. Story Continues Presenter : Brianna S. Cagle, PhD, Research Scientist, Perspective Therapeutics [203Pb]Pb-VMT-α-NET Presentation Two : Impact of molar activity on [ 203 Pb]Pb-VMT-α-NET biodistribution profile in mice bearing neuroendocrine tumor xenograft Summary : Hematotoxicity limits radiopharmaceutical therapy (RPT) targeting somatostatin receptor 2 (“SSTR2”). Somatostatin agonists and antagonists bind to bone marrow cells and lymphocytes in humans and mice. The molar activity (“MA”) of a given RPT impacts radioactivity absorbed dose to normal tissues and tumors by changing the “hot” to “cold” stoichiometry. The purpose of this study was to develop an understanding of how the MA of SSTR2 agonist [ 203 Pb]Pb-VMT-α-NET (an imaging surrogate for [ 212 Pb]Pb-VMT-α-NET) impacts its biodistribution in tumor-free and SSTR2+ tumor bearing mice. Overall findings of the study demonstrated that the MA of [ 203 Pb]Pb-VMT-α-NET impacts the uptake in low-SSTR2 expressing organs. Results suggest that a “sweet spot” of total injected mass of [ 203 Pb]Pb-VMT-α-NET (<0.5 nmol) can be found in which the tumor to normal tissue ratios can be found. These findings exemplify a strategy that Perspective uses to optimize the therapeutic window of its proprietary RPTs. Presenter : D. Liu, PhD, Senior Research Scientist, Perspective Therapeutics Presentation Three : Interim results of [ 212 Pb]VMT-α-NET Targeted Alpha Therapy in Metastatic Gastro-entero-pancreatic Neuroendocrine Tumors: First In-human Clinical Results on Safety and Efficacy Summary : This is an investigator led, exploratory first-in-human use of [ 212 Pb]Pb-VMT-α-NET in adult patients with unresectable or metastatic SSTR2-positive neuroendocrine tumors ("NETs") and medullary thyroid carcinomas in a compassionate setting in India. This presentation, with a data cutoff date of September 15, 2024, focused on 10 patients with well-differentiated gastroenteropancreatic NETs (“GEP-NETs”). These patients were treated with [ 212 Pb]Pb-VMT-α-NET at a dosage of 67 µCi/kg body weight, with an interval of 8 weeks for up to 6 cycles. Treatment was well-tolerated with a modest and manageable adverse effect profile. Confirmed tumor responses per RECIST 1.1 were observed in six of ten GEP-NETs patients. The investigator concluded that the toxicity profile suggests the potential for dose escalation to achieve optimal treatment responses. Long term survival data will mature with continued follow-up. Presenter : Ishita B. Sen, DNB, Director and Head of the Department of Nuclear Medicine & Molecular Imaging at Fortis Memorial Research Institute (FMRI), Gurgaon Presentation Four : Image guided evaluation of [ 212 Pb]VMT-α-NET in metastatic Neuroendocrine tumors: Bio distribution and Dosimetry Summary : The aim of this analysis was to assess the biodistribution and image-guided dosimetric estimates of [ 212 Pb]Pb-VMT-α-NET peptide used for targeted alpha therapy in patients with GEP-NETs. Dosimetry estimates were collected from five of the patients as described in Presentation Three. The results demonstrated that the SPECT/CT imaging with [ 212 Pb]Pb-VMT-α-NET showed prompt tumor accumulation, high tumor retention, and rapid renal excretion in all patients. Overall, the findings suggest that post-treatment imaging of [ 212 Pb]Pb-VMT-α-NET is feasible and can serve as a valuable tool to evaluate and monitor patients through a full course of treatment. Further investigation in a greater number of patients is needed to develop and validate post-treatment Pb-212 imaging and dosimetry for clinical translation. Presenter: Dharmender Malik, MD, Fortis Memorial Research Institute (FMRI) Investigator-Led Preclinical Research Presentation Five : Evaluation and Design of New Chelators using Density Functional Theory Modeling: Implications for Improved Performance of 203 Pb/ 212 Pb-based Theranostic for Cancers Summary : One of the key factors leading to the success of targeted theranostics is the sophisticated matching of the chelator to the specific radionuclide, ensuring stability and targeted delivery. The purpose of this study was to evaluate multiple chelators for imaging and therapeutic radionuclides, and newly designed chelator compositions to potentially optimize for the Pb isotopes. Multiple chelators extensively used in targeted theranostics (i.e., DOTA, NOTA, and TETA) were investigated with imaging (e.g., 68 Ga, 64 Cu, 111 In) and therapeutic radionuclides (e.g., 177 Lu, 90 Y). The study revealed how each chelator reacts with imaging and therapeutic radionuclides, optimizing the chelating form for the respective radionuclides. The results confirmed the superior performance of the modified chelators when compared to conventional forms and thus validated this computational strategy to be an effective tool for customizing chelators for targeted theranostics. Ongoing studies are expected to suggest novel chelator compositions designed for improved stability and specificity for 203 Pb/ 212 Pb theranostic radionuclides. Presenter : Dongyoul Lee, PhD, Department of Physics and Chemistry, Korea Military Academy Presentation Six : Development of 203 Pb Labeled SSTR-Targeting Peptides as Surrogates for 212 Pb Labeled Radiopharmaceuticals Summary : SSTR2 is a key target molecule for peptide receptor radionuclide therapy (PRRT) in NETs. The purpose of this study was to assess the feasibility of 203 Pb labeled peptides as surrogates for 212 Pb labeled radiopharmaceuticals. SSTR2 agonists (i.e., DOTATATE, PSC-PEG2-TOC) and antagonists (i.e., DOTA-LM3, DOTA-PEG2-LM3) were radiolabeled with 203 Pb and evaluated to identify the most promising candidate for PRRT. The SSTR2-targeting peptides investigated exhibited excellent radiolabeling performance and stability with 203 Pb. Imaging data suggested the feasibility of using 203 Pb-labeled radiopharmaceuticals as surrogates for 212 Pb counterparts, potentially enabling 203 Pb image-guided 212 Pb therapy for NETs. Further studies are planned to evaluate the therapeutic potential of 212 Pb labeled radiopharmaceutical candidates in NET mouse models. Presenter : Jung Woo Byun, Department of Nuclear Medicine, Seoul National University For more details on the presentations, the abstract book is available online at https://link.springer.com/article/10.1007/s00259-024-06838-z. About Perspective Therapeutics, Inc. Perspective Therapeutics, Inc., is a radiopharmaceutical development company that is pioneering advanced treatment applications for cancers throughout the body. The Company has proprietary technology that utilizes the alpha emitting isotope 212 Pb to deliver powerful radiation specifically to cancer cells via specialized targeting peptides. The Company is also developing complementary imaging diagnostics that incorporate the same targeting peptides, which provide the opportunity to personalize treatment and optimize patient outcomes. This "theranostic" approach enables the ability to see the specific tumor and then treat it to potentially improve efficacy and minimize toxicity. The Company's melanoma (VMT01) and neuroendocrine tumor (VMT-α-NET) programs have entered Phase 1/2a imaging and therapy trials for the treatment of metastatic melanoma and neuroendocrine tumors at several leading academic institutions. The Company has also developed a proprietary 212 Pb generator to secure key isotopes for clinical trial and commercial operations. For more information, please visit the Company's website at www.perspectivetherapeutics.com . Safe Harbor Statement This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Statements in this press release that are not statements of historical fact are forward-looking statements. Words such as "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "estimate," "believe," "predict," "potential," or "continue" or the negative of these terms or other similar expressions are intended to identify forward-looking statements, though not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include express or implied statements concerning, among other things, the Company's ability to pioneer and develop advanced treatment applications for cancers throughout the body; expectations regarding the timing and advancement of the Company's clinical and preclinical programs; the potential of [ 212 Pb]Pb-PSV359 to treat a variety of epithelial-derived cancers; the feasibility of post-treatment imaging of [ 212 Pb]Pb-VMT-α-NET to evaluate and monitor patients; the potential to modify chelators for targeted theranostics; the potential identification of novel chelator compositions to offer improved stability and specificity for 203 Pb/ 212 Pb theranostic radionuclides; the feasibility of using 203 Pb-labeled radiopharmaceuticals as surrogates for 212 Pb counterparts, potentially enabling 203 Pb image-guided 212 Pb therapy for NETs; plans for future studies to evaluate the therapeutic potential of 212 Pb labeled radiopharmaceutical candidates; the ability of the Company's proprietary technology that utilizes the alpha-emitting isotope 212 Pb to deliver powerful radiation specifically to cancer cells via specialized targeting peptides; the opportunity to personalize treatment and optimize patient outcomes using the Company's complementary imaging diagnostics that incorporate the same targeting peptides; the Company's expectation that its "theranostic" approach enables the ability to see specific tumors and then treat them to potentially improve efficacy and minimize toxicity; the Company's ability to develop a proprietary 212 Pb generator to secure key isotopes for clinical trial and commercial operations; expectations regarding the potential market opportunities for the Company's product candidates; the potential functionality, capabilities, and benefits of the Company's product candidates and the potential application of these product candidates for other disease indications; the Company's expectations, beliefs, intentions, and strategies regarding the future; the Company's intentions to improve important aspects of care in cancer treatment; and other statements that are not historical fact. The Company may not actually achieve the plans, intentions, or expectations disclosed in the forward-looking statements, and you should not place undue reliance on the forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause the Company's actual results to differ materially from the results described in or implied by the forward-looking statements. Certain factors that may cause the Company's actual results to differ materially from those expressed or implied in the forward-looking statements in this press release are described under the heading "Risk Factors" in the Company's most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "SEC"), in the Company's other filings with the SEC, and in the Company's future reports to be filed with the SEC and available at www.sec.gov . Forward-looking statements contained in this news release are made as of this date. Unless required to do so by law, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. CONTACT: Perspective Therapeutics IR: Annie Cheng ir@perspectivetherapeutics.com Russo Partners, LLC Nic Johnson PerspectiveIR@russopr.com View Comments Terms and Privacy Policy Privacy Dashboard Recommended Stories
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		SELECT "pl_content"."created_dt", "pl_content"."updated_dt", "pl_content"."status_id", "pl_content"."id", "pl_content"."key", "pl_content"."fetch_ref_id", "pl_content"."ticker", "pl_content"."publish_dt", "pl_content"."external_id", "pl_content"."published_by", "pl_content"."title", "pl_content"."summary", "pl_content"."tags", "pl_content"."url", "pl_content"."author", "pl_content"."author_reputation_score", "pl_content"."content_length", "pl_content"."sentiment_positive", "pl_content"."sentiment_negative", "pl_content"."sentiment_neutral", "pl_content"."sentiment", "pl_content"."relevance_score", "pl_content"."votes_positive", "pl_content"."votes_negative", "pl_content"."is_processing_flag", "pl_content"."data_source_id", "pl_content"."publisher_id" FROM "pl_content" WHERE "pl_content"."id" = 3515061 LIMIT 21SELECT ••• FROM "pl_content" WHERE "pl_content"."id" = 3515061 LIMIT 21		1.25
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1405) content = Content.objects.get(id=content_id)
		SELECT "pl_content_content"."created_dt", "pl_content_content"."updated_dt", "pl_content_content"."status_id", "pl_content_content"."id", "pl_content_content"."key", "pl_content_content"."content", "pl_content_content"."content_ref_url", "pl_content_content"."content_id" FROM "pl_content_content" WHERE "pl_content_content"."content_id" = 3515061 ORDER BY "pl_content_content"."id" ASC LIMIT 1SELECT ••• FROM "pl_content_content" WHERE "pl_content_content"."content_id" = 3515061 ORDER BY "pl_content_content"."id" ASC LIMIT 1		5.26
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1411) content_content = ContentContent.objects.filter(details=content).first()
		SELECT "pl_data_source"."created_dt", "pl_data_source"."updated_dt", "pl_data_source"."status_id", "pl_data_source"."id", "pl_data_source"."name", "pl_data_source"."type", "pl_data_source"."url", "pl_data_source"."description", "pl_data_source"."weight", "pl_data_source"."class_name", "pl_data_source"."class_params_json" FROM "pl_data_source" WHERE "pl_data_source"."id" = 2 LIMIT 21SELECT ••• FROM "pl_data_source" WHERE "pl_data_source"."id" = 2 LIMIT 21		0.91
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1415) data_source = content.data_source

Static files (717 found, 2 used)

Static file paths

None

Static file apps

grappelli
django.contrib.admin
django_htmx
app.core
django_extensions
debug_toolbar

Static files

css/pennyloupe.css: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/static/css/pennyloupe.css
img/penny_loupe_logo.png: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/static/img/penny_loupe_logo.png

django.contrib.staticfiles.finders.AppDirectoriesFinder (717 files)

Templates (6 rendered)

Template path

templates

Templates

ticker_content_detail.html: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/templates/ticker_content_detail.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653336d40>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653f0d1c0>>'} {'content_detail': {'content': <Content: Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine - >, 'content_content': <ContentContent: Content ID: 1846765>, 'data_source': <DataSource: Yahoo Finance News>, 'publisher': None}, 'ticker': 'CATX'}
base.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/base.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653336d40>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653f0d1c0>>'} {'content_detail': {'content': <Content: Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine - >, 'content_content': <ContentContent: Content ID: 1846765>, 'data_source': <DataSource: Yahoo Finance News>, 'publisher': None}, 'ticker': 'CATX'}
components/leftnav.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/leftnav.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653336d40>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653f0d1c0>>'} {'content_detail': {'content': <Content: Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine - >, 'content_content': <ContentContent: Content ID: 1846765>, 'data_source': <DataSource: Yahoo Finance News>, 'publisher': None}, 'ticker': 'CATX'} {'block': <Block Node: leftnav. Contents: [<TextNode: '\n <div'>, <IncludeNode: template=<FilterExpression '"components/leftnav.html"'>>, <TextNode: '\n </di'>]>}
components/header.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/header.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653336d40>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653f0d1c0>>'} {'content_detail': {'content': <Content: Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine - >, 'content_content': <ContentContent: Content ID: 1846765>, 'data_source': <DataSource: Yahoo Finance News>, 'publisher': None}, 'ticker': 'CATX'} {'block': <Block Node: header. Contents: [<TextNode: '\n\n '>, <IncludeNode: template=<FilterExpression '"components/header.html"'>>, <TextNode: '\n\n '>]>}
components/ticker_subnav.html: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/templates/components/ticker_subnav.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653336d40>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653f0d1c0>>'} {'content_detail': {'content': <Content: Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine - >, 'content_content': <ContentContent: Content ID: 1846765>, 'data_source': <DataSource: Yahoo Finance News>, 'publisher': None}, 'ticker': 'CATX'} {'block': <Block Node: content. Contents: [<TextNode: '\n\n <div class="uk-flex'>, <IncludeNode: template=<FilterExpression '"components/ticker_subnav.html"'>>, <TextNode: '\n <!-- /SUB NAV--'>, <Variable Node: content_detail.content.title>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.id>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.external_id>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.author>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.publish_dt>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.summary>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.tags>, <TextNode: '</td>\n '>, <IfNode>, <TextNode: '\n '>, <Variable Node: content_detail.content.sentiment_negative>, <TextNode: '   \n '>, <Variable Node: content_detail.content.sentiment_neutral>, <TextNode: '   \n '>, <Variable Node: content_detail.content.sentiment_positive>, <TextNode: '<br/>\n '>, <django.template.defaulttags.WidthRatioNode object at 0x7ff656abd450>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.sentiment_neutral>, <TextNode: '" style="width:'>, <django.template.defaulttags.WidthRatioNode object at 0x7ff653f5c250>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.sentiment_positive>, <TextNode: '" style="width:'>, <django.template.defaulttags.WidthRatioNode object at 0x7ff653f2c510>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.relevance_score>, <TextNode: '</td>\n '>, <IfNode>, <TextNode: '\n '>, <IfNode>, <TextNode: '\n <li clas'>, <Variable Node: content_detail.data_source.name>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.type>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.url>, <TextNode: '" target="_blank">'>, <Variable Node: content_detail.data_source.url>, <TextNode: '</a></td>\n '>, <Variable Node: content_detail.data_source.description>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.weight>, <TextNode: '</td>\n '>]>} {'ticker': 'CATX'}
components/footer.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/footer.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653336d40>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653f0d1c0>>'} {'content_detail': {'content': <Content: Perspective Therapeutics Presents Updates at the 37th Annual Congress of the European Association of Nuclear Medicine - >, 'content_content': <ContentContent: Content ID: 1846765>, 'data_source': <DataSource: Yahoo Finance News>, 'publisher': None}, 'ticker': 'CATX'} {'block': <Block Node: footer. Contents: [<TextNode: '\n '>, <IncludeNode: template=<FilterExpression '"components/footer.html"'>>, <TextNode: '\n '>]>}

Context processors

django.template.context_processors.csrf: Toggle context
{'csrf_token': <SimpleLazyObject: <function csrf.<locals>._get_val at 0x7ff653336d40>>}
django.template.context_processors.debug: Toggle context
{}
django.template.context_processors.request: Toggle context
{'request': <WSGIRequest: GET '/ticker/CATX/content/3515061'>}
django.contrib.auth.context_processors.auth: Toggle context
{'user': <SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653f0d1c0>>)}
django.contrib.messages.context_processors.messages: Toggle context
{'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/CATX/content/3515061'>>, 'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30, 'ERROR': 40}}

Cache calls from 1 backend

Summary

Total calls	Total time	Cache hits	Cache misses
0	0 ms	0	0

Commands

add	get	set	get_or_set	touch	delete	clear	get_many	set_many	delete_many	has_key	incr	decr	incr_version	decr_version
0	0	0	0	0	0	0	0	0	0	0	0	0	0	0

Signals

Signal	Receivers
class_prepared
connection_created	register_type_handlers
got_request_exception
m2m_changed
post_delete
post_init
post_migrate	create_permissions, create_contenttypes
post_save	create_initial_trade_position
pre_delete
pre_init
pre_migrate	inject_rename_contenttypes_operations
pre_save
request_finished	close_old_connections, close_caches, reset_urlconf
request_started	reset_queries, close_old_connections
setting_changed	reset_cache, clear_cache_handlers, update_installed_apps, update_connections_time_zone, clear_routers_cache, reset_template_engines, storages_changed, clear_serializers_cache, language_changed, localize_settings_changed, file_storage_changed, complex_setting_changed, root_urlconf_changed, static_storage_changed, static_finders_changed, auth_password_validators_changed, user_model_swapped, update_toolbar_config, reset_hashers, update_level_tags, uninstall_if_needed, clear_caches, StaticFilesStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties

Path	Location
.DS_Store	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/.DS_Store
grappelli/.DS_Store	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/.DS_Store
grappelli/js/grappelli.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/grappelli.js
grappelli/js/jquery.grp_related_m2m.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_m2m.js
grappelli/js/jquery.grp_autocomplete_fk.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_fk.js
grappelli/js/jquery.grp_autocomplete_generic.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_generic.js
grappelli/js/jquery.grp_timepicker.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_timepicker.js
grappelli/js/jquery.grp_collapsible_group.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_collapsible_group.js
grappelli/js/jquery.grp_related_generic.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_generic.js
grappelli/js/jquery.grp_related_fk.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_fk.js
grappelli/js/jquery.grp_collapsible.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_collapsible.js
grappelli/js/grappelli.min.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/grappelli.min.js
grappelli/js/jquery.grp_autocomplete_m2m.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_m2m.js
grappelli/js/jquery.grp_inline.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_inline.js
grappelli/images/spritesheet-1694777276.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/spritesheet-1694777276.png
grappelli/images/backgrounds/loading-small.gif	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/loading-small.gif
grappelli/images/backgrounds/changelist-results.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/changelist-results.png
grappelli/images/backgrounds/ui-sortable-placeholder.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/ui-sortable-placeholder.png
grappelli/images/backgrounds/nav-grabber.gif	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/nav-grabber.gif
grappelli/images/backgrounds/messagelist.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/messagelist.png
grappelli/images/icons/ui-datepicker-next.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/ui-datepicker-next.png
grappelli/images/icons/link-external-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/link-external-small_hover.png
grappelli/images/icons/tools-arrow-up-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-arrow-up-handler_hover.png
grappelli/images/icons/date-hierarchy-back.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/date-hierarchy-back.png
grappelli/images/icons/tools-delete-handler-predelete.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-delete-handler-predelete.png
grappelli/images/icons/breadcrumbs-rtl.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/breadcrumbs-rtl.png
grappelli/images/icons/datepicker_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/datepicker_hover.png
grappelli/images/icons/tools-trash-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-trash-handler_hover.png
grappelli/images/icons/selector-add-m2m-vertical_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/selector-add-m2m-vertical_hover.png
grappelli/images/icons/tools-related-remove-handler-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-remove-handler-small_hover.png
grappelli/images/icons/sorted-descending.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/sorted-descending.png
grappelli/images/icons/breadcrumbs_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/breadcrumbs_hover.png
grappelli/images/icons/tools-viewsite-link_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-viewsite-link_hover.png
grappelli/images/icons/object-tools-add-link.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/object-tools-add-link.png
grappelli/images/icons/tools-related-edit-handler-small-disabled.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-edit-handler-small-disabled.png
grappelli/images/icons/tools-related-remove-handler-small-disabled.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-remove-handler-small-disabled.png
grappelli/images/icons/sorted-ascending.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/sorted-ascending.png
grappelli/images/icons/link-internal-rtl-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/link-internal-rtl-small_hover.png
grappelli/images/icons/pulldown-handler_selected.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/pulldown-handler_selected.png
grappelli/images/icons/tools-delete-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-delete-handler_hover.png

Content Detail

Versions

Time

Resource usage

Browser timing

Settings from app.settings

Headers

Request headers

Response headers

WSGI environ

Request

View information

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

Static files (717 found, 2 used)

Static file paths

Static file apps

Static files

django.contrib.staticfiles.finders.AppDirectoriesFinder (717 files)

Templates (6 rendered)

Template path

Templates

Context processors

Cache calls from 1 backend

Summary

Commands

Signals