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  Title	Earnings call transcript: Esperion Therapeutics Q4 2025 misses EPS but sees revenue surge
  ID	30785846
  External ID	fe3a3aaf3833bda6f5a511f4591bced8
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  Published Date	March 10, 2026, 12:56 p.m.
  Summary	Earnings call transcript: Esperion Therapeutics Q4 2025 misses EPS but sees revenue surge
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  URL	https://ca.investing.com/news/transcripts/earnings-call-transcript-esperion-therapeutics-q4-2025-misses-eps-but-sees-revenue-surge-93ch-4505128
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  Content	Esperion Therapeutics reported its fourth-quarter 2025 earnings, revealing an EPS of $0.22, falling short of the forecasted $0.29, marking a 24.14% negative surprise. Despite this miss, the company's revenue reached $168.45 million, surpassing expectations slightly and representing a 144% year-over-year increase. In pre-market trading, Esperion's stock rose by 7.24% to $3.26, reflecting investor optimism about the company's revenue performance and future prospects. Key Takeaways Esperion's revenue grew by 144% year-over-year, driven by a substantial increase in collaboration revenue. The company missed EPS expectations, reporting $0.22 against a forecast of $0.29. Stock price rose by 7.24% in pre-market trading despite the EPS miss. Esperion ended the year with a strong cash position and reduced debt. The company is optimistic about future growth through new product launches and strategic partnerships. Company Performance Esperion Therapeutics showcased robust revenue growth in the fourth quarter of 2025, marking it as the company's best quarter yet. This growth was largely attributed to a significant increase in collaboration revenue, bolstered by a one-time milestone payment from Otsuka. The company faced challenges in meeting EPS expectations, which may raise concerns about profitability among investors. According to InvestingPro data, the company posted a negative EPS of $0.54 over the last twelve months, and analysts do not anticipate profitability this year. For investors seeking deeper insights, InvestingPro offers comprehensive analysis including 6 additional ProTips and detailed financial health scores for ESPR. Financial Highlights Revenue: $168.45 million, up 144% year-over-year. Earnings per share: $0.22, compared to a forecast of $0.29. US net product revenue: $43.7 million, a 38% increase from Q4 2024. Collaboration revenue: $124.7 million, a 232% increase from Q4 2024. Earnings vs. Forecast Esperion's earnings per share of $0.22 fell short of the expected $0.29, resulting in a negative surprise of 24.14%. This miss contrasts with the company's strong revenue performance, which slightly exceeded forecasts by 0.1%. Market Reaction Despite the EPS miss, Esperion's stock rose by 7.24% in pre-market trading, reaching $3.26. This increase reflects investor confidence in the company's revenue growth and future strategic initiatives. The stock has delivered an impressive 92% return over the past year, though it's down 18% year-to-date. Trading at $3.04, the stock remains well above its 52-week low of $0.69 but below its 52-week high of $4.17. According to InvestingPro analysis, the stock currently appears overvalued relative to its Fair Value estimate—a key consideration for investors evaluating entry points. Those interested in valuation insights can explore the Most Overvalued stocks list for broader market context. Outlook & Guidance Esperion projects full-year 2026 operating expenses to range between $225 million and $255 million, including $15 million in non-cash stock compensation expenses. The company plans to launch new products and expand internationally, which could drive future growth. Executive Commentary CEO Tim Mayleben stated, "2025 has been our best year on record, and we are poised to continue this momentum into 2026 with strategic product launches and partnerships." This confidence in future growth is echoed by the company's strong cash position and debt reduction efforts. Risks and Challenges The EPS miss may impact investor confidence in the short term. Rising operating expenses, particularly in R&D and legal costs, could pressure profitability. Sustaining high revenue growth rates may be challenging without significant new product contributions. Q&A Analysts inquired about the sustainability of revenue growth and the impact of increased operating expenses on future profitability. Management emphasized their strategic focus on new product launches and international expansion to drive long-term growth. Full transcript - Esperion Therapeutics Inc (ESPR) Q4 2025: Operator : Ladies and gentlemen, thank you for standing by and welcome. At this time, all participants are in a listen-only mode. Following the presentation, there will be a question and answer session. Please be advised that today's conference call will be recorded. I would now like to hand the conference over to Tiffany Aldrich, Head of Corporate Communications for Esperion Therapeutics. Please go ahead. David Amsellem, Analyst, Piper Sandler 1: Thank you, operator. Good morning, and welcome to Esperion's fourth quarter and full year 2025 earnings conference call. With us today are Sheldon Koenig, President and CEO, and Ben Halladay, CFO. Other members of the executive team will be available for Q&A following our prepared remarks. We issued a press release earlier this morning detailing the content of today's call. A copy can be found on the investor page of our website, together with a copy of the presentation that we will also be referencing. I want to remind callers that the information discussed on the call today is covered under the safe harbor provisions of the Private Securities Litigation Reform Act. I caution listeners that management will be making forward-looking statements. Actual results could differ materially from those stated or implied by our forward-looking statements due to risks and uncertainties associated with the business. These forward-looking statements are qualified in their entirety by the cautionary statements contained in today's press release and in our SEC filings. The content of this conference call contains time-sensitive information that is accurate only as of the date of this live broadcast, March 10, 2026. We undertake no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this conference call and webcast. As a reminder, this conference call and webcast are being recorded and archived. We will begin the call with prepared remarks and then open the line for your questions. I'll now turn the call over to Sheldon. David Amsellem, Analyst, Piper Sandler 0: Thank you, Tiffany. Good morning, everyone, and thank you for joining us. 2025 was a defining and transformative year for our company, representing our strongest performance to date. We fortified our financial foundation, continued our strong commercial execution, and reinforced our commitment to the patient to inspire everything we do. Because of this work, we enter 2026 with strong momentum and a clear path forward. We recently introduced our Vision 2040, which defines our long-term ambition and the roadmap to achieve it. I'm proud to say we are already executing on that vision. Our planned acquisition of Corstasis Therapeutics significantly enhances our company and demonstrates our Vision 2040 strategy in action. It is a transformational step that will give us two powerful global franchises to grow. Our global bempedoic acid portfolio and Enbumyst, a first-in-class intranasal diuretic addressing meaningful needs in heart failure care. This combination of addressing bad cholesterol and heart failure will align with our existing cardiology footprint, accelerate growth, and most importantly, offer patients more impactful, patient-friendly options across the continuum of cardiometabolic disease. The acquisition of Corstasis is a catalyst for additional long-term value and a testament to our commitment to building a larger and sustainably profitable company. Our priority is to grow these two franchises to their multi-billion-dollar potential. Turning to the progress we've made building the U.S. bempedoic acid franchise, we achieved strong prescription growth and broadened payer coverage as we focused our sales and marketing efforts on statin-tolerant patients, which represents a significant market opportunity. Together, this allowed us to drive Q4 year-over-year sales by 38%, increase retail prescription equivalents by 34%, and expand the number of unique healthcare practitioners prescribing NEXLETOL and NEXLIZET by nearly 25%. We anticipate 2026 to continue this momentum, driven by our strong reimbursement and expect favorable positioning in the US dyslipidemia guidelines, which should be released imminently. In addition, the American College of Cardiology scientific statement on inflammation and cardiovascular disease formally recognized the link between inflammation measured by hsCRP and ASCVD. The authors provide a call to action to implement broad screening of hsCRP for primary and secondary prevention patients in combination with LDL cholesterol screening. Importantly, the American Heart Association corroborated this recognition in its hsCRP toolkit for professionals in which bempedoic acid is recognized as an agent to reduce hsCRP. I will remind everyone that NEXLETOL and NEXLIZET are the only non-statins proven to reduce hsCRP by up to 46%. Looking ahead, we are advancing our two triple combination programs and expect to complete the clinical and regulatory requirements to commercialize in 2027. Based on published data, triple combination therapies have demonstrated the potential to reduce LDL cholesterol up to 70%, a level of efficacy that could rival current injectables and emerging oral treatments. Now turning to our continued international expansion. Our global partners delivered yet another year of substantial growth. Daiichi Sankyo Europe increased fourth quarter royalty revenue by 51% compared to fourth quarter 2024. They expanded access to 30 countries, including receiving favorable payer reimbursement and launching in France, and have treated more than 700,000 patients to date. During the fourth quarter, our Japanese partner, Otsuka, successfully launched NEXLETOL in Japan following regulatory approval and a highly favorable national health insurance price listing. Early market reception has exceeded even the most optimistic expectations. With Japan representing the world's third-largest market for cardiovascular disease prevention, and given the strong pricing environment, we believe this momentum positions us for significant and sustained growth in 2026 and beyond. Additional launches and regulatory progress continue across Canada, Israel, Australia, and New Zealand. Moving on to our pipeline progress. We continue to advance a new generation of highly specific ACLY inhibitors targeting serious metabolic and inflammatory diseases. We nominated ESP-2001 as our next development candidate for the treatment of primary sclerosing cholangitis, or PSC, a devastating disease with no approved therapies. ESP-2001 is now advancing through IND-enabling studies, and we plan to be in the clinic by the end of this year. Collectively, our progress across commercial execution, pipeline advancement, and global expansion reinforces the strength of the strategy we have put in place and sets us up for a powerful next phase of growth. Now let me turn to a review of our exciting agreement to acquire Corstasis Therapeutics. This transaction will provide us with global rights to its FDA-approved therapy, Enbumyst, a first-in-class intranasal diuretic approved in September 2025 for the treatment of edema associated with congestive heart failure, hepatic disease, and renal disease. This acquisition is a highly strategic and transformational step for Esperion. It will expand our presence beyond chronic lipid management into a large, complementary cardiometabolic market and meaningfully accelerate our growth trajectory. In addition, Corstasis is advancing a subcutaneous pipeline, including a multi-dose pen injector, which has the potential to unlock additional market opportunities. Enbumyst is available now to address a significant unmet need and aligns directly with our US cardiology-focused commercial infrastructure, enabling immediate cross-selling synergies with the physicians already prescribing NEXLETOL and NEXLIZET. Enbumyst was developed in partnership with cardiologists specializing in heart failure, who recognized the fact that one in four patients are readmitted to a hospital within 30 days, driving significant healthcare costs, despite current products in the market attempting to address this. To reduce readmission rates and provide an easy-to-use at-home treatment, these cardiologists developed Enbumyst, a differentiated, patient-friendly alternative to oral and injectable diuretics. As the only nasal spray loop diuretic, it bypasses GI absorption issues, offers rapid onset, and supports at-home management of fluid overload. This creates a compelling opportunity to reduce hospital admissions and readmissions, an area of profound unmet need in heart failure, where nearly two-thirds of the 1 million hospitalizations each year are primarily for diuresis, many of which may be avoidable. Financially, this acquisition provides Esperion with a highly attractive entry point into a $4+ billion U.S. outpatient market. Heart failure market and significant runway for utilization growth. Moving forward, our plan is to fully leverage our commercial team's cardiovascular sales presence to scale adoption and accelerate revenue contribution. We are also planning our strategy to launch Enbumyst in ex-US markets as we have global rights. The transaction is expected to close in the second quarter of 2026. Enbumyst strengthens our foundation, expands our commercial reach, and uniquely positions us to attack the growing global cardiometabolic disease epidemic now and into the future. With that, let me turn the call over to our Chief Financial Officer, Ben Halladay, for a review of our financials. Ben Halladay, Chief Financial Officer, Esperion Therapeutics : Thank you, Sheldon. Good morning, everyone, and thank you for joining us today. Our fourth quarter and full-year 2025 financial results can be found in the press release we issued this morning, and more detail will be included in our upcoming 10-K. 2025 was the company's best year on record, and our financial results reflect the important advances the team has made. We continued to make progress through 2025 towards sustained profitability, and our commitment to growing the bempedoic acid franchise has laid the groundwork that enabled us to enter into new markets and diversify our revenue streams. We ended the year with $55 million less in debt by paying off the 2025 convertible note stub, and thanks to our disciplined approach to expense management, we ended the year with $167.9 million in cash. We are still in a strong cash position, and we are well-capitalized to successfully implement the Enbumyst launch. Fourth quarter 2025 total revenue was $168.4 million, an increase of 144%. US net product revenue was $43.7 million compared to $31.6 million for the comparable period in 2024, an increase of approximately 38%. Collaboration revenue was $124.7 million compared to $37.6 million for the comparable period in 2024, an increase of approximately 232% driven by a one-time payment of $90 million received from Otsuka related to regulatory approval and favorable NHI price listing, increases in royalty sales within our partner territories and product sales to our collaboration partners from our supply agreements. Turning to the rest of the P&L. For the fourth quarter 2025, research and development expenses were $13.9 million compared to $11 million for the comparable period in 2024, an increase of approximately 26%. Selling, general and administrative expenses were $41.4 million compared to $36.9 million for the comparable period in 2024, an increase of 12%. The increase quarter-over-quarter was primarily related to increased legal costs associated with the ANDA litigation. As mentioned before, we ended 2025 with $167.9 million in cash and cash equivalents and a balance sheet that continues to improve every year. Our strong, stable balance sheet gives us the opportunity to build not only our NEXLETOL and NEXLIZET franchise, but to integrate Corstasis and successfully launch Enbumyst as well. Our new operating expense guidance, updated to reflect modest increases, shows the strong synergies we expect between our product lines. We now project full year 2026 operating expenses to be in the range of $225 million-$255 million, including $15 million in non-cash expenses related to stock compensation. With that, I will now turn the call back over to Sheldon for closing remarks. David Amsellem, Analyst, Piper Sandler 0: Thank you, Ben. In closing, 2025 marked a year of meaningful execution, strategic expansion and business transformation, and we are truly a new Esperion. We strengthened every core dimension of our company, from commercial performance to global partnerships, from scientific leadership to long-term strategy. Now we have an agreement to add a synergistic high-value asset with a planned acquisition of Corstasis. We expect this transaction to be a growth accelerant and a foundational building block of our Vision 2040 strategy. We are energized by the opportunities ahead, and we remain relentlessly focused on delivering innovative therapies to patients, value to shareholders and sustainable long-term growth to our business. Thank you for joining us this morning. Operator, we are now ready to open the call for questions. Operator : Thank you. To ask a question, please press star one one on your telephone and wait for your name to be announced. To withdraw your question, please press star one one again. Our first question is going to come from Joe Pantginis with H.C. Wainwright. Your line is open. Joe Pantginis, Analyst, H.C. Wainwright : Hey, guys. Good morning. Thanks for taking the question. I just wanted to go back and maybe review or get reminded again with regard to Corstasis, which was a nice addition to the sales bag for your field force. Just curious, with the device itself, you know, what is your ability or what is the capacity now with regard to, say, approximate numbers of patients to treat and any capacity needed, you know, moving forward? Then what are the potential next steps that are required for the auto-injector? Thanks a lot. David Amsellem, Analyst, Piper Sandler 0: Great. Thanks, Joe. As it relates to capacity, we're fine. We're in good shape there. There's nothing really needed. We've got product and we're ready to go. You know, there are physicians right now, you know, some of which are using it, but there's never really a full-scale launch, and that's what we are working on and, you know, thinking about. Obviously, we have to wait for the deal to close, which as we've mentioned before, will sometime be in early April. Your second question was related to next steps of the auto-injector. Joe Pantginis, Analyst, H.C. Wainwright : Auto-injector. David Amsellem, Analyst, Piper Sandler 0: Yeah. We'll plan to update you probably after the deal closes of where we are in the pipeline, but it is something we want to mention because it is coming. The reason why we're mentioning it is that it just gives physicians choice. What I will say is that one thing that we've heard already from key opinion leaders is the ease of use of this drug, and that's what patients need. As you know, a patient suffering from heart failure, you know, it's very alarming. People can't breathe, they can't sleep, et cetera. To be able to just, you know, puff something into your nose and get relief, that's a big deal. You know, we're focused on that now. Again, the auto-injector will be something in the future that will allow optionality. Joe Pantginis, Analyst, H.C. Wainwright : Thank you. Operator : Thank you. Our next question is going to come from Kristen Kluska with Cantor Fitzgerald. Your line's open. Kristen Kluska, Analyst, Cantor Fitzgerald : Hi. Good morning, everybody. Thanks for taking my questions. I wanted to ask one on the ACC guidelines. When looking at their abstract titles online, it certainly gives the hint that we're going to be getting something soon. Just curious if you could talk about the latest that you've been hearing on that front, given the conference is in two and a half weeks here, and then also what you as a company are doing to prepare for that conference. I know that this will also be an opportunity for the clinicians to get training at the conference, but what can Esperion do to prepare from that side? David Amsellem, Analyst, Piper Sandler 0: Yeah. Thanks, Kristin. Let me start off, and I'll kick it over to John to talk about what we're doing as an organization. The intel was always the fact that we would be getting the guidelines sometime in the first quarter. At one point, we were told early in the first quarter. Obviously, here we are in March. Our best intelligence right now is that it will come out before ACC. It'll probably come out a week before ACC. We've seen some advertisements online that other people have probably seen by ACC, talking about a satellite symposium that they're going to hold sometime in the March nineteenth, March twentieth. We're thinking that's probably when they could be released. Before I turn it over to John, the one thing, again, we don't know what they say, but we feel very confident that, you know, we should be well-represented. We also believe that there'll be harmonization between what we saw in Europe and U.S. guidelines. You heard what I said in our prepared remarks around hs-CRP. There's been a lot of references to bempedoic acid even before the guidelines in different areas about where we fit as a therapy, which have all pointed to positive signals. Let me turn it over to John to talk about how we're preparing for it. John, Commercial/Sales Leadership, Esperion Therapeutics : Hey, Kristen. As you can imagine, the team has been preparing for quite some time for this event, and we have a very in-depth cross-functional plan for the entire organization and the medical community as soon as the guidelines are released. It will range from materials for our customer-facing field members, as both medical as well as commercial and the sales team, as well as a broad digital program and outreach. We're ready and waiting. Kristen Kluska, Analyst, Cantor Fitzgerald : Thanks. On that note, given that we kinda got a little bit of a preview about what to expect in Europe, curious if you've talked to your partners about what has happened to them in the months after, and in terms of whether the number, you know, obviously you guys as an organization are working closely with physicians, but how much of this was inbound from people that were newly introduced or perhaps getting reintroduced? I know you also launched in the midst of a pandemic here. Is there potential that people are gonna be coming internally to you because they'll be reintroduced to the product with these new guidelines? David Amsellem, Analyst, Piper Sandler 0: I think, you know, what we saw when we actually talked about the CLEAR Outcomes study going back to 2023, you saw this huge bolus of awareness. You know, some of the things that John talked about, some of the things we'll be doing after ACC, we view this as another opportunity to get a lot of awareness. You know, similar to what Daiichi Sankyo saw when the European guidelines were released. I've told this story before where key opinion leaders in Europe said congratulations to Daiichi Sankyo. Their chief executive officer said, You know, because of the guidelines, he said, "Well, it's the first time ever that I hear somebody else talking about what a great product this is other than you." I think that's what's important, is that now you have these third-party guideline writers who are very respected, who will be talking about our placement in the guidelines and where we should be utilized. I think that's gonna bring more physicians to the table. It's also gonna help physicians really understand that I do need to be thinking about this therapy with this type of patient and this type of diagnosis, et cetera. It's nothing but what I would say upside for us as it relates to awareness, prescribing, you name it. We'll be ready. You know, the one thing, you know, John and his team, after the European guidelines came out, we are out there four days after those guidelines with a detail aid telling physicians in the United States what Europe had done. It just shows you how quick we can react and be ready. We will take full advantage of this meeting as a, you know, very large awareness event, just like we did in 2023. Kristen Kluska, Analyst, Cantor Fitzgerald : Great. Thank you. Operator : Thank you. The next question is gonna come from Georgia Bank with Jefferies. Your line is open. Georgia Bank, Analyst, Jefferies : Hi. Thank you. Georgia Bank on the line for Jefferies. Thanks for taking our questions. I guess, piggybacking on the conversation around the EU guidelines, maybe you could just talk a little bit about the impact that you've seen in the US already from those guidelines changing the EU. Then what kind of incremental impact would you see in the US given the guideline inclusion that's coming, as you said, imminently? Any changes in the sales force that you going forward, and where would you see opportunities to add coverage or dial back on territories that might be less profitable? Thank you. David Amsellem, Analyst, Piper Sandler 0: John, do you wanna do the territory part, and I'll do the guidelines part? John, Commercial/Sales Leadership, Esperion Therapeutics : Yeah, sure. Georgia, good question as it relates to kind of sales force coverage. We continually evaluate the needs of the organization based on demand, productivity, profitability, and the needs of our growing portfolio. Once the Corstasis acquisition closes and we integrate Enbumyst into our operations, we will plan to expand the sales team modestly to ensure appropriate coverage of key settings, including the new markets such as key heart failure clinics and IDNs and health systems for that hospital discharge opportunity. We look forward to providing additional updates as the year progresses, and we continue to evaluate our coverage in light of the guidelines as well to make sure that, you know, we deploy our teams in places where we continue to see success. David Amsellem, Analyst, Piper Sandler 0: Thanks, John. As it relates to European guidelines and effect on U.S. prescribing and how that sets up for the U.S., let me just first say, in Europe it's more qualitative. They don't really get prescription data, et cetera. As you know, we look at patient data, and you've seen in our presentation that we delivered today and in our prepared remarks. Daiichi Sankyo now has treated over 700,000 patients with this drug. In Germany alone, as you know, you have to use bempedoic acid before you can go to a PCSK9. That was established even before the guidelines. The guidelines reinforced the decision by AMNOG, which is a division of IQWiG in Germany that makes these healthcare technology assessments. We've talked about France. In France, they'll be launching. I know that the guidelines were received very favorably there. It's the second-largest market in Europe, and they are already off to a fast start. As you know, Organon has partnered with Daiichi Sankyo to launch there and also in the Nordics. From a US perspective, again, it's more qualitative, and the feedback that we've gotten from the field is that physicians responded very favorably to the European guidelines. I think the sentiment was, hopefully, we'll see the same thing in the US. I think that's what we're all waiting for. As it relates to US guidelines and effect on prescribing, similar to the answer I gave to Kristin earlier, we think this is nothing but tailwinds for us. I mean, the fact that, again, we can have a third-party advocate, it's important to be in guidelines. The fact that we would now be in guidelines, this is our first opportunity, that's gonna be a really big deal for us. You know, future competition, which we get questions of, they won't be in the guidelines. Remember, one of the reasons why we think we'll have prominence in the guidelines and why we have prominence in the European guidelines is because of the 14,000-patient CLEAR Outcomes study, which is a game-changing study. We'll see why and how that will be interpreted into the US guidelines as well. It's undeniable and, you know, it's just, it's data that's important, and physicians will be, you know, keen to get those guidelines and apply them. Ben Halladay, Chief Financial Officer, Esperion Therapeutics : Great. Thank you. Operator : Thank you. The next question comes from Serge Belanger with Needham. Your line is open. Serge Belanger, Analyst, Needham : Hi. Good morning. Thanks for taking our questions. The first one regarding the triple combo products. Based on your FDA interactions and the development path you've taken, what kind of label do you expect for these products? Is it gonna be similar to NEXLIZET? Secondly, regarding guidance, I guess for Ben, I know you don't provide top-line guidance, but can you give us a little more color on the collaboration revenue line for 2026, just given that there's a couple moving parts with Otsuka launching in Japan and the manufacturing transfer that's going to affect those numbers? Thanks. David Amsellem, Analyst, Piper Sandler 0: Let me start with the triple combination. Just as a reminder to everyone, the triple combination therapy is bempedoic acid plus ezetimibe plus a statin, so essentially NEXLIZET plus a statin. We're doing two different statins, atorvastatin and rosuvastatin. We're looking at a low-dose strategy. If you even look at ESC and what they showed in their presentation of the guidelines, if you look at the addition of a statin such as atorva or rosuva to NEXLIZET, you get close to a 70% reduction in LDL. We've done our own study with atorvastatin 10 milligrams and showed close to a 70% reduction in LDL. The label itself will not carry the outcomes data that you see in that for NEXLETOL. That is okay because, you know, people know the background of these drugs, statins and also, bempedoic acid, whether it be NEXLETOL or NEXLIZET. It's pretty much just a label without the outcomes data that will speak to efficacy. You know, we've already market researched this as well, Serge, and, you know, physicians get it. What I will say is that this is something that not only are physicians really interested in in Europe, but they're really interested in here in the United States. The reason for that is because there is more of the shift to this poly pill within a therapeutic area strategy. The fact that you can give somebody one pill that will get them to, you know, perhaps 70% LDL reduction speaks so, you know, to so many benefits, as it relates to compliance, persistence, et cetera. We're excited about it and, you know, look forward to the day where we can bring it to market. Ben? Ben Halladay, Chief Financial Officer, Esperion Therapeutics : Yeah. Morning, Serge. Thank you for the question. When it comes to the partnership revenue line, there are a lot of moving parts this year. I mean, first and foremost, we won't have another $91 million in milestones because of the regulatory work that we had in 2025. Primarily, I think the big drivers are gonna be, we expect royalties to continue increasing both from the addition of Otsuka, as well as the fact that Daiichi Sankyo continues to grow in their existing markets and added France in first quarter of this year. On top of that, the tech transfer will start flowing through the P&L, and we expect that manufacturing will continue to ramp up over the course of this year so that partner reimbursement line will tick down. Associated with that will actually be an increase in the gross margin based on the margins that we've discussed on these calls before. A lot of moving pieces, but I think overall, we expect to continue to see that partner reimbursement line continue to add significant value to the company and enhance over the course of the year. Operator : Thank you. Our next question will come from Jason Zemansky with Bank of America. Your line's open. Jason Zemansky, Analyst, Bank of America : Good morning. Congrats on the quarter, and thanks for taking our question. It seems the last two quarters, while you've broadened access on the payer front, there have been a number of concessions. Moving forward, can you discuss what the risks look like for additional concessions in 2026, especially given, as you mentioned earlier, there are potential, new competitors, poised to enter the market? Thanks. David Amsellem, Analyst, Piper Sandler 0: Oh, Jason, good. Thanks for the question, but when you say concessions, what are you speaking to? Are you speaking to price or? Jason Zemansky, Analyst, Bank of America : Yes, exactly. David Amsellem, Analyst, Piper Sandler 0: Okay. Yeah. No, we don't see anything as it relates to concessions. We're set with our contracts. You know, we have 90% coverage in commercial, 90% now in Medicare. If anything, I think it's competition that's gonna have to make concessions. Keep in mind, again, we have an outcome study, competition doesn't. I know you speak to the MK-0616 product. Keep in mind that they don't have outcomes until 2030, and payers really look for outcomes in order to avoid step edits and, you know, significant prior authorizations. We're good. No concessions needed from us. John, Commercial/Sales Leadership, Esperion Therapeutics : Got it. Thanks for the color. Operator : Thank you. The next question's gonna come from David Amsellem with Piper Sandler. Your line's open. David Amsellem, Analyst, Piper Sandler : Thanks. I just have a couple. Coming back to the triple combination, what's your market research revealed regarding the extent to which it could expand your overall bempedoic acid franchise patient footprint, on both sides of the Atlantic or frankly, globally? That's number one. Number two, as you think about the triple combo, I mean, the messaging historically has been about statin intolerance. Do you think the triple combo changes that message or muddles that message? And how do you square the triple combo with the historical messaging about statin intolerance and the utility of bempedoic acid in that context? That's number two. And then lastly, regarding your Vision 2040 plan, maybe just thinking about the sales force and how you're expanding the product offering. What is the optimal number over the next 2-3 years? I should say optimal number of products that you think your commercial organization can carry in its bag, so to speak, or put differently, what's the extent to which there's gonna be other assets you're gonna be bringing in over the next couple of years? Thank you. David Amsellem, Analyst, Piper Sandler 0: Sure. Yeah. Let me start off with the triple combination and the excitement in Europe and U.S. two-market research. Succinctly, it's very high, David. I mean, the fact of the matter is cardiovascular disease is still the number one killer. Even despite all the therapies that we have out there, it still is the number one killer and continues to grow. The excitement around triple combination has been very high in both Europe and the United States. As a matter of fact, it was reinforced with the European guidelines, where the whole emphasis was on triple combination. There they talk about triple combination without even having the pill. It's more a combination of therapies to get patients to goal. I think we finally have reached that point where similar to diabetes, similar to hypertension, one drug does not get you to the goal that you need. You need multiple. It's very exciting from that perspective. Regarding statin intolerance, it doesn't muddy the waters at all because remember, the definition of statin intolerance is really three. One, a patient who doesn't want to take a statin at all. Two, a patient who can't tolerate a statin. Three, a patient who can take a statin, but only a low dose. Keep in mind for triple combination, it's really about looking at that low-dose statin with bempedoic acid. The definition of statin intolerant, as a reminder, is not just a patient who can't take a statin at all. It's just about the dose of a statin. Keep in mind, titrating a statin only gives you a 6% additional LDL efficacy. It's meaningless. That's why it's better just to go to these other therapies. Again, something that was reinforced in the European guidelines, and I think you'll see reinforced in the US guidelines. Before I turn it over to John to talk about number of representatives, et cetera, because I think there's maybe two questions in there. You know, we're good now. We have bempedoic acid, NEXLIZET, NEXLETOL. We're doing the Corstasis acquisition. We talked about Vision 2040 having five products. Keep in mind, primary sclerosing cholangitis is a product, if successful, would be out in 2030, 2031. But from a BE perspective, we're good where we are now. You know, we'll cool our jets with BE. We'll always look at the environment. As it relates to number of field personnel, et cetera, just overall, I'll turn it over to John. John, Commercial/Sales Leadership, Esperion Therapeutics : Yeah. Thanks, Sheldon. I, you know, David, I look at the question twofold. One is the size of the sales organization and number of reps, as well as to your question, the optimal number of products within an existing bag. It really depends upon, one, the target overlap and the customer call points. It also depends upon where the product or products are within their life cycle. We still are in the early stages of the life cycle of NEXLIZET and NEXLETOL, and obviously we're in the very beginning stages of the life cycle of the Enbumyst. You know, in two to three years from now, you know, we could envision having a field that has David Amsellem, Analyst, Piper Sandler 0: 2-4 products in the bag. Again, it depends upon call points, synergies, as well as life cycle. Getting beyond that 4 sometimes gets questionable. But we have seen it where, you know, more mature products can be in the bag, so it could be 4 or 5. But again, we're not at that stage yet from a maturity and a product life cycle standpoint, but we'll continue to evaluate, you know, how the products fit as we evolve into our Vision 2040. Ben Halladay, Chief Financial Officer, Esperion Therapeutics : Okay, that's helpful, caller. Thanks everyone. Operator : Thank you. The next question will come from Paul Choi with Goldman Sachs. Your line is open. Paul Choi, Analyst, Goldman Sachs : Hi, thank you. Good morning, and thanks for taking our questions. My first question is another one just on the triple combinations, and I was wondering if you had any offer any narrowing of the range in 2027 where you might potentially file the NDAs for the two drugs. My second question is on Corstasis. Can you maybe just remind us if there are any clinical development obligations or post-market obligations at this point for Enbumyst? And then also just sort of in 2026 whether you anticipate any additional clinical updates from some from the ongoing clinical development or presentation development programs. Thank you. David Amsellem, Analyst, Piper Sandler 0: Great. Thanks, Paul. Let me, well, Ben, why don't you start with the Corstasis one? Ben Halladay, Chief Financial Officer, Esperion Therapeutics : Yeah, Paul, on the Corstasis side, there are some small PMR studies that need to be done, but we've included all those in the updated expense guidance. They're minimal. It's not something that we really expect to move the needle all too much. David Amsellem, Analyst, Piper Sandler 0: Thanks, Ben. It relates to triple combination and narrowing down the date. I'm just gonna say right now, Paul, we'll continue to update you, but right now, sticking to 2027. There's competitive reasons for saying that as well, but we'll definitely continue to update you on our progress. Again, to me, the triple combination reinforces our commitment to, again, making bempedoic acid franchise as successful as possible while also making our Corstasis acquisition, once approved, equally successful. Operator : Thank you. I am showing no further questions in the queue at this time. I would now like to turn the call back to Sheldon for closing remarks. David Amsellem, Analyst, Piper Sandler 0: Great. Well, thank you so much. I again want to thank everyone for your ability to attend our earnings today. Again, 2025 was just a great year for us, our best year ever, fourth quarter, our best quarter ever, and really appreciate all the questions as well and look forward to updating all of you in the future as we continue along here at Esperion. Thank you so much. Have a great rest of the week. Operator : This concludes today's conference call. Thank you for participating, and you may now disconnect. This article was generated with the support of AI and reviewed by an editor. 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