Title	Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial
ID	5945323
External ID	7470973373
Author	Unknown
Published Date	Jan. 16, 2025, 4:46 a.m.
Summary	Patients From September 10, 2021 to July 28, 2022, a total of 357 participants were screened and 275 participants were randomly assigned to lerociclib plus fulvestrant (n = 137) or placebo plus fulve
Tags	None
URL	https://www.nature.com/articles/s41467-025-56096-2
Sentiment	Negative: 0.46993 Neutral: 0.48508 Positive: 0.04499
Relevance	0.00000

Content ID	3623254
Key	c39ccca9-6ab3-4f73-847a-1e444acec23d
Content	Patients From September 10, 2021 to July 28, 2022, a total of 357 participants were screened and 275 participants were randomly assigned to lerociclib plus fulvestrant (n = 137) or placebo plus fulvestrant (n = 138; Fig. 1) arms. The data cut-off date was December 2, 2022. Baseline characteristics were well balanced between the two arms (Table 1). At baseline, 174 patients (63.3%) exhibited visceral metastatic lesions including 104 patients (37.8%) with liver metastasis, while 41 patients (14.9%) showed bone-only metastatic lesions. All patients had previously shown resistance to ET, with 70 patients (25.5%) displaying primary ET resistance (defined as disease relapsed while receiving the first 2 years of (neo)adjuvant ET or progressed while receiving the first 6 months of ET for ABC19,20) and 205 patients (74.5%) displaying secondary drug resistance (defined as disease relapsed while on adjuvant ET but after the first 2 years, or relapsed within 12 months of completing adjuvant ET, or progressive disease (PD) > 6 months after initiating ET for ABC, while on ET19,20). The majority of patients (92.4%) had received prior chemotherapy, while during the relapsed/metastatic phase, and 80 patients (29.1%) received first-line chemotherapy. Nearly half of the patients (43.3%) were pre/perimenopausal women or men. Table 1 Patient and disease baseline characteristics Full size table Treatment At the data cut-off, a higher percentage of patients were continuing with the study treatment in the lerociclib arm (63.5%) compared to the placebo arm (40.6%). Treatment discontinuation was mainly due to disease progression (34.3% in the lerociclib arm, 52.2% in the placebo arm). The median duration of drug exposure was 6.28 months (range: 0.6–12.1) in the lerociclib arm and 4.86 months (range: 0.4–12.5) in the placebo arm. The median average daily doses of lerociclib and matching-placebo were 283.67 mg and 297.55 mg, respectively. Efficacy A total of 125 PFS events, including documented disease progression or death without documented progression, were observed in the ITT population. Specifically, there were 48 events (35.0%) in the lerociclib arm (137 participants) and 77 events (55.8%) in the placebo arm (138 participants). The median follow-up time was 7.36 months for the lerociclib arm and 7.33 months for the placebo arm. The lerociclib arm demonstrated a superior median PFS of 11.07 months, compared with 5.49 months in the placebo arm (HR: 0.451; 95% CI: 0.311–0.656; P = 0.000016; Fig. 2A). BICR-assessed analysis provided consistent results for PFS (HR: 0.353; 95% CI: 0.228–0.547; P = 0.000002; Fig. 2B). The addition of lerociclib to fulvestrant improved PFS across all pre-specified patient subgroups, including patients with poor prognosis, such as primary ET resistance (HR: 0.374; 95% CI: 0.182–0.769), liver metastasis (HR: 0.487; 95% CI: 0.297–0.796), ≥4 metastatic sites (HR: 0.326; 95% CI: 0.160–0.665), received one line of chemotherapy for recurrent/metastatic disease (HR: 0.286; 95% CI: 0.138–0.593), and pre/perimenopausal women or men (HR: 0.471; 95% CI: 0.258–0.860) (Fig. 3). The pre-specified sensitivity analysis for investigator-assessed PFS, excluding patients (1) who had less than 80% of treatment compliance (9 patients, all due to COVID-19 pandemic); or (2) who didn’t have any post-treatment radiological assessments (3 patients); or (3) whose baseline radiological assessment was uncomplete to allow appropriate post-treatment efficacy assessment (1 patient), further supported the primary analysis. The median PFS from the sensitivity analysis was 11.07 months in the lerociclib arm and 5.49 months in the placebo arm (HR: 0.462; 95% CI: 0.316, 0.676, p < 0.0001). Fig. 2: Kaplan–Meier analyses of progression-free survival in the intent-to-treat population (n = 275 patients). A Investigator-assessed and B Blinded Independent Central Review-assessed. HR hazard ratio. The hazard ratio (HR) was derived from a stratified Cox proportional hazards model, and the one-sided p-value was derived from the Log-Rank test. Source data are provided as a Source Data file. Full size image Fig. 3: Subgroup analysis of progression-free survival (PFS) assessed by Investigator in the intent-to-treat population (n = 275 patients). HRs are for lerociclib versus placebo. PFS HRs are indicated by diamonds and 95% CIs are indicated by the crossing horizontal lines. Diamond size is proportional to the sample size of each patient subgroup. HRs were estimated based on the unstratified Cox proportional hazards model for the stratification factor related subgroups including menopausal status, visceral metastasis, liver metastasis; stratified Cox proportional hazards model for other subgroups and overall HR. ECOG Eastern Cooperative Oncology Group, ER estrogen receptor, HR hazard ratio, PR progesterone receptor. Source data are provided as a Source Data file. Full size image The investigator-assessed ORR (based on confirmed response) was 23.4% (95% CI: 16.27–30.44%) in the lerociclib arm and 8.7% (95% CI: 3.99–13.40%) in the placebo arm (Table 2). Three CRs (2.2%) were achieved in the lerociclib arm compared with no CRs (0%) in the placebo arm. Among patients with measurable disease at baseline, the ORR was 26.9% (95% CI: 18.92–34.86%) in the lerociclib arm and 9.9% (95% CI: 4.59–15.24%) in the placebo arm (Table 2). Due to the relatively short follow-up duration, DOR was not mature as of the data cut-off and the median DOR had not been reached in both arms, with 38 responders (86.4%) continuing the treatment at the time of the analysis. The DCR and CBR (lerociclib arm vs. placebo arm) were 81.8% (95% CI: 75.28–88.22%) vs. 71.0% (63.44–78.58%) and 48.2% (95% CI: 39.81–56.54%) vs. 24.6% (95% CI: 17.45–31.83%), respectively (Table 2). The ORR/DCR/CBR/DOR assessed by BICR were in line with the investigator assessments (Supplementary Table 1). Table 2 Best overall response (investigator-assessed) Full size table As of the data cut-off, OS results were not yet mature, with 9 deaths (6.6%) in the lerociclib arm and 13 deaths (9.4%) in the placebo arm (HR: 0.630, 95% CI: 0.267–1.484; median OS: not reached in both arms). An ad hoc analysis of OS was conducted (DCO: March 30, 2024) with a median follow-up duration of 23 months, at which time there were 32 and 43 deaths in the lerociclib arm and placebo arm, respectively. Median OS was not reached in either arm and the HR was 0.649 (95% CI: 0.410, 1.028) (Supplementary Fig. 1). Pharmacokinetic (PK) samples were collected before the study drug dosing in the morning on Cycle 1 Day 15, Cycle 2 Day 1, Cycle 3 Day 1, Cycle 4 Day 1, respectively. The mean of serum concentrations of lerociclib and its metabolite G1T30 ranged from 11.515 ng/mL to 16.556 ng/mL, and from 1.2545 ng/mL to 1.9259 ng/mL, respectively. The variations of the mean at different cycles are within the standard deviations of the mean at each cycle. Safety The safety population was the same as the ITT population (lerociclib, n = 137; placebo, n = 138). The most common treatment-emergent AEs of any grade were neutropenia, leukopenia, and anemia (Table 3). Grade 3 or higher AEs were reported in 57.7% and 15.2% of the patients in the lerociclib arm and the placebo arm, respectively (Table 4). The grade 3 or 4 AEs occurring in ≥3% of the patients in lerociclib arm were neutropenia (grade 3: 41.6%, grade 4: 5.1%, no febrile neutropenia), leukopenia (23.4%, grade 3 only), and thrombocytopenia (grade 3: 2.2%, grade 4: 1.5%) (Table 3). Table 3 Treatment-emergent adverse events Full size table Table 4 Treatment-emergent adverse events summary Full size table Diarrhea was reported in 19.7% (no ≥grade 3) and 3.6% patients in lerociclib and placebo arms, respectively. AEs of ECG QTc prolongation (any grade) occurred in 4 patients (2.9%; all grade 1) receiving lerociclib plus fulvestrant and 2 patients (1.4%; 1 (0.7%) grade 2; 1 (0.7%) grade 3) receiving placebo plus fulvestrant. None of the prolonged QTc events led to treatment discontinuation. Pneumonitis due to any reason was reported by 2 (1.5%) patients in the lerociclib arm and 3 (2.2%) patients in the placebo arm; 1 patient in each arm reported grade 3 pneumonitis. Only 1 patient (0.7%), in the lerociclib plus fulvestrant arm, discontinued study treatment due to grade 3 pneumonitis. No venous thromboembolic events (VTE) were reported. Serious AEs (SAEs) were reported in 5.8% of patients in the lerociclib arm and 8.0% of patients in the placebo arm (Table 4). SAEs that could possibly be attributed to the study drug were observed in 4.4% of patients on lerociclib and 4.3% of patients on placebo. SAEs in the lerociclib arm were sporadic with one patient (0.7%) in each of the AEs including neutropenia, leukopenia, infectious pneumonia, gastrointestinal infections, oral mucositis, vomiting, and interstitial lung disease. The dose reduction as a result of AEs occurred in 52 (38.0%) patients receiving lerociclib compared with 3 (2.2%) receiving placebo. Only 1 patient (0.7%) discontinued lerociclib treatment due to AE. There were 9 deaths (6.6%) in the lerociclib arm, one of which was due to AE (cerebral infarction, not considered treatment related by the investigator), while there were 13 deaths (9.4%) in the placebo arm, none of which were due to AEs.
Content Reference URL	None

Publisher Name	Nature
Publisher URL	https://www.nature.com/
Description	None
Trust Flow Score	61
Citation Flow Score	58

Data Source Name	Quantexa News
Data Source Type	news
Data Source URL	https://app.aylien.com/dashboard
Description	Welcome to Quantexa News API — the most powerful way to aggregate, filter, and integrate global news data into your apps and models.
Weight	10

DJDT

Versions

Package	Name	Version
Django		5.0.3
Python		3.11.8
coverage	Coverage	7.4.4
debug_toolbar	Debug Toolbar	4.3.0
django_extensions	Django Extensions	3.2.3
grappelli	Grappelli	3.0.8

Time

Resource usage

Resource	Value
User CPU time	57.878 msec
System CPU time	12.122 msec
Total CPU time	70.000 msec
Elapsed time	77.537 msec
Context switches	5 voluntary, 4 involuntary

Browser timing

Timing attribute	Timeline	Milliseconds since navigation start (+length)

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Headers

Request headers

Key	Value
Accept	/
Accept-Encoding	gzip, br, zstd, deflate
Host	pennyloupe.com
User-Agent	Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Response headers

Key	Value
Content-Type	text/html; charset=utf-8

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key	Value
CONTENT_LENGTH
CONTENT_TYPE
PATH_INFO	/ticker/III/content/5945323
QUERY_STRING
REMOTE_ADDR	18.117.82.179
REQUEST_METHOD	GET
SCRIPT_NAME
SERVER_NAME	pennyloupe.com
SERVER_PORT	443
SERVER_PROTOCOL	HTTP/1.1

Request

View information

View function	Arguments	Keyword arguments	URL name
`app.core.views.app.ticker_content_detail`	`()`	`{'content_id': 5945323, 'ticker': 'III'}`	`ticker_content_detail`

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

default 4.63 ms (4 queries )

	Query		Timeline	Time (ms)	Action
		SELECT "pl_content"."created_dt", "pl_content"."updated_dt", "pl_content"."status_id", "pl_content"."id", "pl_content"."key", "pl_content"."fetch_ref_id", "pl_content"."ticker", "pl_content"."publish_dt", "pl_content"."external_id", "pl_content"."published_by", "pl_content"."title", "pl_content"."summary", "pl_content"."tags", "pl_content"."url", "pl_content"."author", "pl_content"."author_reputation_score", "pl_content"."content_length", "pl_content"."sentiment_positive", "pl_content"."sentiment_negative", "pl_content"."sentiment_neutral", "pl_content"."sentiment", "pl_content"."relevance_score", "pl_content"."votes_positive", "pl_content"."votes_negative", "pl_content"."is_processing_flag", "pl_content"."data_source_id", "pl_content"."publisher_id" FROM "pl_content" WHERE "pl_content"."id" = 5945323 LIMIT 21SELECT ••• FROM "pl_content" WHERE "pl_content"."id" = 5945323 LIMIT 21		1.09
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1405) content = Content.objects.get(id=content_id)
		SELECT "pl_content_content"."created_dt", "pl_content_content"."updated_dt", "pl_content_content"."status_id", "pl_content_content"."id", "pl_content_content"."key", "pl_content_content"."content", "pl_content_content"."content_ref_url", "pl_content_content"."content_id" FROM "pl_content_content" WHERE "pl_content_content"."content_id" = 5945323 ORDER BY "pl_content_content"."id" ASC LIMIT 1SELECT ••• FROM "pl_content_content" WHERE "pl_content_content"."content_id" = 5945323 ORDER BY "pl_content_content"."id" ASC LIMIT 1		1.89
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1411) content_content = ContentContent.objects.filter(details=content).first()
		SELECT "pl_content_publisher"."created_dt", "pl_content_publisher"."updated_dt", "pl_content_publisher"."status_id", "pl_content_publisher"."id", "pl_content_publisher"."name", "pl_content_publisher"."url", "pl_content_publisher"."domain", "pl_content_publisher"."description", "pl_content_publisher"."weight", "pl_content_publisher"."trust_flow_score", "pl_content_publisher"."citation_flow_score" FROM "pl_content_publisher" WHERE "pl_content_publisher"."id" = 2153 LIMIT 21SELECT ••• FROM "pl_content_publisher" WHERE "pl_content_publisher"."id" = 2153 LIMIT 21		0.86
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1414) publisher = content.publisher
		SELECT "pl_data_source"."created_dt", "pl_data_source"."updated_dt", "pl_data_source"."status_id", "pl_data_source"."id", "pl_data_source"."name", "pl_data_source"."type", "pl_data_source"."url", "pl_data_source"."description", "pl_data_source"."weight", "pl_data_source"."class_name", "pl_data_source"."class_params_json" FROM "pl_data_source" WHERE "pl_data_source"."id" = 5 LIMIT 21SELECT ••• FROM "pl_data_source" WHERE "pl_data_source"."id" = 5 LIMIT 21		0.80
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1415) data_source = content.data_source

Static files (717 found, 2 used)

Static file paths

None

Static file apps

grappelli
django.contrib.admin
django_htmx
app.core
django_extensions
debug_toolbar

Static files

css/pennyloupe.css: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/static/css/pennyloupe.css
img/penny_loupe_logo.png: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/static/img/penny_loupe_logo.png

django.contrib.staticfiles.finders.AppDirectoriesFinder (717 files)

Templates (6 rendered)

Template path

templates

Templates

ticker_content_detail.html: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/templates/ticker_content_detail.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff652fa36a0>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff652e45080>>'} {'content_detail': {'content': <Content: Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial - Unknown>, 'content_content': <ContentContent: Content ID: 3623254>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Nature>}, 'ticker': 'III'}
base.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/base.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff652fa36a0>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff652e45080>>'} {'content_detail': {'content': <Content: Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial - Unknown>, 'content_content': <ContentContent: Content ID: 3623254>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Nature>}, 'ticker': 'III'}
components/leftnav.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/leftnav.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff652fa36a0>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff652e45080>>'} {'content_detail': {'content': <Content: Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial - Unknown>, 'content_content': <ContentContent: Content ID: 3623254>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Nature>}, 'ticker': 'III'} {'block': <Block Node: leftnav. Contents: [<TextNode: '\n <div'>, <IncludeNode: template=<FilterExpression '"components/leftnav.html"'>>, <TextNode: '\n </di'>]>}
components/header.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/header.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff652fa36a0>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff652e45080>>'} {'content_detail': {'content': <Content: Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial - Unknown>, 'content_content': <ContentContent: Content ID: 3623254>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Nature>}, 'ticker': 'III'} {'block': <Block Node: header. Contents: [<TextNode: '\n\n '>, <IncludeNode: template=<FilterExpression '"components/header.html"'>>, <TextNode: '\n\n '>]>}
components/ticker_subnav.html: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/templates/components/ticker_subnav.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff652fa36a0>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff652e45080>>'} {'content_detail': {'content': <Content: Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial - Unknown>, 'content_content': <ContentContent: Content ID: 3623254>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Nature>}, 'ticker': 'III'} {'block': <Block Node: content. Contents: [<TextNode: '\n\n <div class="uk-flex'>, <IncludeNode: template=<FilterExpression '"components/ticker_subnav.html"'>>, <TextNode: '\n <!-- /SUB NAV--'>, <Variable Node: content_detail.content.title>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.id>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.external_id>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.author>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.publish_dt>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.summary>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.tags>, <TextNode: '</td>\n '>, <IfNode>, <TextNode: '\n '>, <Variable Node: content_detail.content.sentiment_negative>, <TextNode: '   \n '>, <Variable Node: content_detail.content.sentiment_neutral>, <TextNode: '   \n '>, <Variable Node: content_detail.content.sentiment_positive>, <TextNode: '<br/>\n '>, <django.template.defaulttags.WidthRatioNode object at 0x7ff654269b10>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.sentiment_neutral>, <TextNode: '" style="width:'>, <django.template.defaulttags.WidthRatioNode object at 0x7ff654269f10>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.sentiment_positive>, <TextNode: '" style="width:'>, <django.template.defaulttags.WidthRatioNode object at 0x7ff65426a350>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.relevance_score>, <TextNode: '</td>\n '>, <IfNode>, <TextNode: '\n '>, <IfNode>, <TextNode: '\n <li clas'>, <Variable Node: content_detail.data_source.name>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.type>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.url>, <TextNode: '" target="_blank">'>, <Variable Node: content_detail.data_source.url>, <TextNode: '</a></td>\n '>, <Variable Node: content_detail.data_source.description>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.weight>, <TextNode: '</td>\n '>]>} {'ticker': 'III'}
components/footer.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/footer.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff652fa36a0>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff652e45080>>'} {'content_detail': {'content': <Content: Lerociclib plus fulvestrant in patients with HR+/HER2− locally advanced or metastatic breast cancer who have progressed on prior endocrine therapy: LEONARDA-1 a phase III randomized trial - Unknown>, 'content_content': <ContentContent: Content ID: 3623254>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Nature>}, 'ticker': 'III'} {'block': <Block Node: footer. Contents: [<TextNode: '\n '>, <IncludeNode: template=<FilterExpression '"components/footer.html"'>>, <TextNode: '\n '>]>}

Context processors

django.template.context_processors.csrf: Toggle context
{'csrf_token': <SimpleLazyObject: <function csrf.<locals>._get_val at 0x7ff652fa36a0>>}
django.template.context_processors.debug: Toggle context
{}
django.template.context_processors.request: Toggle context
{'request': <WSGIRequest: GET '/ticker/III/content/5945323'>}
django.contrib.auth.context_processors.auth: Toggle context
{'user': <SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff652e45080>>)}
django.contrib.messages.context_processors.messages: Toggle context
{'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/III/content/5945323'>>, 'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30, 'ERROR': 40}}

Cache calls from 1 backend

Summary

Total calls	Total time	Cache hits	Cache misses
0	0 ms	0	0

Commands

add	get	set	get_or_set	touch	delete	clear	get_many	set_many	delete_many	has_key	incr	decr	incr_version	decr_version
0	0	0	0	0	0	0	0	0	0	0	0	0	0	0

Signals

Signal	Receivers
class_prepared
connection_created	register_type_handlers
got_request_exception
m2m_changed
post_delete
post_init
post_migrate	create_permissions, create_contenttypes
post_save	create_initial_trade_position
pre_delete
pre_init
pre_migrate	inject_rename_contenttypes_operations
pre_save
request_finished	close_old_connections, close_caches, reset_urlconf
request_started	reset_queries, close_old_connections
setting_changed	reset_cache, clear_cache_handlers, update_installed_apps, update_connections_time_zone, clear_routers_cache, reset_template_engines, storages_changed, clear_serializers_cache, language_changed, localize_settings_changed, file_storage_changed, complex_setting_changed, root_urlconf_changed, static_storage_changed, static_finders_changed, auth_password_validators_changed, user_model_swapped, update_toolbar_config, reset_hashers, update_level_tags, uninstall_if_needed, clear_caches, StaticFilesStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties

Path	Location
.DS_Store	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/.DS_Store
grappelli/.DS_Store	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/.DS_Store
grappelli/js/grappelli.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/grappelli.js
grappelli/js/jquery.grp_related_m2m.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_m2m.js
grappelli/js/jquery.grp_autocomplete_fk.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_fk.js
grappelli/js/jquery.grp_autocomplete_generic.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_generic.js
grappelli/js/jquery.grp_timepicker.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_timepicker.js
grappelli/js/jquery.grp_collapsible_group.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_collapsible_group.js
grappelli/js/jquery.grp_related_generic.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_generic.js
grappelli/js/jquery.grp_related_fk.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_fk.js
grappelli/js/jquery.grp_collapsible.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_collapsible.js
grappelli/js/grappelli.min.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/grappelli.min.js
grappelli/js/jquery.grp_autocomplete_m2m.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_m2m.js
grappelli/js/jquery.grp_inline.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_inline.js
grappelli/images/spritesheet-1694777276.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/spritesheet-1694777276.png
grappelli/images/backgrounds/loading-small.gif	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/loading-small.gif
grappelli/images/backgrounds/changelist-results.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/changelist-results.png
grappelli/images/backgrounds/ui-sortable-placeholder.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/ui-sortable-placeholder.png
grappelli/images/backgrounds/nav-grabber.gif	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/nav-grabber.gif
grappelli/images/backgrounds/messagelist.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/messagelist.png
grappelli/images/icons/ui-datepicker-next.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/ui-datepicker-next.png
grappelli/images/icons/link-external-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/link-external-small_hover.png
grappelli/images/icons/tools-arrow-up-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-arrow-up-handler_hover.png
grappelli/images/icons/date-hierarchy-back.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/date-hierarchy-back.png
grappelli/images/icons/tools-delete-handler-predelete.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-delete-handler-predelete.png
grappelli/images/icons/breadcrumbs-rtl.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/breadcrumbs-rtl.png
grappelli/images/icons/datepicker_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/datepicker_hover.png
grappelli/images/icons/tools-trash-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-trash-handler_hover.png
grappelli/images/icons/selector-add-m2m-vertical_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/selector-add-m2m-vertical_hover.png
grappelli/images/icons/tools-related-remove-handler-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-remove-handler-small_hover.png
grappelli/images/icons/sorted-descending.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/sorted-descending.png
grappelli/images/icons/breadcrumbs_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/breadcrumbs_hover.png
grappelli/images/icons/tools-viewsite-link_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-viewsite-link_hover.png
grappelli/images/icons/object-tools-add-link.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/object-tools-add-link.png
grappelli/images/icons/tools-related-edit-handler-small-disabled.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-edit-handler-small-disabled.png
grappelli/images/icons/tools-related-remove-handler-small-disabled.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-remove-handler-small-disabled.png
grappelli/images/icons/sorted-ascending.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/sorted-ascending.png
grappelli/images/icons/link-internal-rtl-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/link-internal-rtl-small_hover.png
grappelli/images/icons/pulldown-handler_selected.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/pulldown-handler_selected.png
grappelli/images/icons/tools-delete-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-delete-handler_hover.png

Content Detail

Versions

Time

Resource usage

Browser timing

Settings from app.settings

Headers

Request headers

Response headers

WSGI environ

Request

View information

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

Static files (717 found, 2 used)

Static file paths

Static file apps

Static files

django.contrib.staticfiles.finders.AppDirectoriesFinder (717 files)

Templates (6 rendered)

Template path

Templates

Context processors

Cache calls from 1 backend

Summary

Commands

Signals