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  Title	Jaguar Health Reports Third Quarter 2025 Financials: Net Q3 2025 Revenue Up Approximately 4% Versus Net Q2 2025 Revenue
  ID	27681963
  External ID	130000069
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  Published Date	Nov. 17, 2025, 7 a.m.
  Summary	This is a paid press release. Contact the press release distributor directly with any inquiries. Jaguar Health Reports Third Quarter 2025 Financials: Net Q3 2025 Revenue Up Approximately 4% Versus Net
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  URL	https://finance.yahoo.com/news/jaguar-health-reports-third-quarter-130000069.html
  Sentiment	Negative: 0.83131    Neutral: 0.02969    Positive: 0.13900
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  Content ID	35371759
  Key	06ee1600-6fc1-4ff6-be25-8c3ebc6df5af
  Content	This is a paid press release. Contact the press release distributor directly with any inquiries. Jaguar Health Reports Third Quarter 2025 Financials: Net Q3 2025 Revenue Up Approximately 4% Versus Net Q2 2025 Revenue ACCESS Newswire · Jaguar Health, Inc. Jaguar Health, Inc. Mon, November 17, 2025 at 7:00 AM CST 10 min read JAGX Initial results of ongoing investigator-initiated proof-of-concept trial demonstrate crofelemer can potentially extend the lives of infants born with intestinal failure due to microvillus inclusion disease (MVID), reducing the volume of the total parenteral support (PS) necessary for them to survive, though with associated toxicity; Groundbreaking PS reduction of up to 37%; No approved treatments exist for MVID Company completed meeting with FDA October 2, 2025 for advice on possible expedited approval pathway to advance its ongoing placebo-controlled trial of crofelemer for potential approval for treatment of MVID REMINDER: Today Jaguar to host investor webcast at 8:30 a.m. Eastern regarding Q3 2025 financials and company updates; Click here to register SAN FRANCISCO, CA / ACCESS Newswire / November 17, 2025 / Jaguar Health, Inc. ( NASDAQ:JAGX ) ("Jaguar" or the "Company") today reported its consolidated third-quarter 2025 financial results. 2025 THIRD QUARTER COMPANY FINANCIAL RESULTS: Net Revenue: The combined net revenue for the Company's prescription products (Mytesi ® , Gelclair ® , and Canalevia ® -CA1), including license revenue, was approximately $3.1 million in the third quarter of 2025, representing an increase of approximately 4% over the combined net revenue in the second quarter of 2025, which totaled approximately $3.0 million, and equaled the combined net revenue for the third quarter of 2024. Mytesi Prescription Volume: Mytesi prescription volume increased by approximately 0.9% in the third quarter of 2025 over the second quarter of 2025, and Mytesi prescription volume in the third quarter of 2025 decreased by 3.6% compared to the volume in the third quarter of 2024. Prescription volume differs from invoiced sales volume, which reflects, among other factors, varying buying patterns among specialty pharmacies in the closed network as they manage their inventory levels. License Revenue: For the third quarter of 2025, the Company recognized license fees of $42,858 from a securities purchase agreement with a European partner. As of September 30, 2025, the total deferred revenue associated with this contract amounts to approximately $595,000. Neonorm ™ : Revenues for the non-prescription Neonorm products were minimal for the third quarters of 2025 and 2024. Three Months Ending Financial Highlights September 30, (in thousands, except per share amounts) 2025 2024 $ change % change Net product revenue $ 3,083 $ 3,108 (25 ) -1 % Loss from operations $ (7,238 ) $ (7,262 ) 24 0 % Net loss attributable to common stockholders $ (9,502 ) $ (9,854 ) 352 -4 % Net loss per share, basic and diluted $ (6.28 ) $ (26.29 ) 20 -76 % Cost of Product Revenue: Total cost of product revenue decreased by approximately $0.01 million, from $0.54 million for the quarter ended September 30, 2024 compared to $0.53 million for the quarter ended September 30, 2025, due to a slight decrease in the average cost of Mytesi bottle lots. Research and Development: The R&D expense decreased by $0.3 million, from $3.7 million for the quarter ended September 30, 2024 compared to $4.0 million for the quarter ended September 30, 2025, primarily due to the conclusion of the Phase 3 OnTarget clinical trial, which reduced trial-related contract manufacturing services and regulatory activities. Sales and Marketing: The Sales and Marketing expense decreased by approximately $0.01 million, from $2.01 million for the quarter ended September 30, 2024 to approximately $2.0 million during the same quarter in 2025. Although personnel and related benefits, together with direct marketing fees, increased by $0.6 million, this was offset by decreased third-party consulting and other expenses of $0.7 million. General and Administrative: The G&A expense increased by approximately $0.3 million, from $3.8 million for the quarter ended September 30, 2024 to $4.1 million during the same quarter in 2025, largely due to increased legal and compliance expenses from financing activities. Loss from Operations: Loss from operations decreased by $0.1 million, from $7.2 million in the quarter ended September 30, 2024 to $7.3 million during the same period in 2025. Net Loss: Net loss attributable to common shareholders decreased by approximately $0.4 million, from $9.9 million in the quarter ended September 30, 2024 to $9.5 million in the same period in 2025. In addition to the loss from operations: Interest income (expense) decreased by $0.2 million, from approximately $0.2 million of interest income for the quarter ended September 30, 2024 to approximately $6,000 of interest expense in the same period in 2025, primarily due to changing the accounting of certain debt instruments designated at Fair Value Option (FVO). The fair value of financial and hybrid instrument designation at FVO decreased by $0.8 million, from a loss of $3.1 million in the three months ended September 30, 2024, to a loss of $2.3 million in the same period in 2025, primarily due to fair value adjustments in liability classified warrants and notes payable designated at FVO. Non-GAAP Recurring EBITDA: Non-GAAP recurring EBITDA for the third quarters of 2025 and 2024 were a net loss of $8.9 million and $8.9 million, respectively. Story Continues Three Months Ending September 30, (in thousands) 2025 2024 $ change % change (unaudited) Net loss attributable to common stockholders $ (9,502 ) $ (9,854 ) (352 ) 4 % Adjustments: Interest income (expense) 6 (162 ) (168 ) 104 % Property and equipment depreciation 17 17 (0 ) -2 % Amortization of intangible assets 463 457 (6 ) -1 % Share-based compensation expense 135 305 170 56 % Loss on extinguishment of debt - - - -100 % Non-GAAP EBITDA (8,881 ) (9,237 ) (357 ) 4 % Note Regarding Use of Non-GAAP Measures The Company supplements its condensed consolidated financial statements presented on a GAAP basis by providing non-GAAP EBITDA and non-GAAP recurring EBITDA, which are considered non-GAAP under applicable SEC rules. Jaguar believes that the disclosure items of these non-GAAP measures provide investors with additional information that reflects the basis upon which Company management assesses and operates the business. These non-GAAP financial measures are not in accordance with GAAP and should not be viewed in isolation or as substitutes for GAAP net sales and GAAP net loss and are not substitutes for, or superior to, measures of financial performance in conformity with GAAP. The Company defines non-GAAP EBITDA as net loss before interest expense and other expense, depreciation of property and equipment, amortization of intangible assets, share-based compensation expense and provision for or benefit from income taxes. The Company defines non-GAAP Recurring EBITDA as non-GAAP EBITDA adjusted for certain non-recurring revenues and expenses. Company management believes that non-GAAP EBITDA and non-GAAP Recurring EBITDA are meaningful indicators of Jaguar's performance and provide useful information to investors regarding the Company's results of operations and financial condition. Participation Instructions for Webcast When: Monday, November 17, 2025 at 8:30 a.m. Eastern Participant Registration & Access Link: Click Here Replay Instructions for Webcast Replay of the webcast on the investor relations section of Jaguar's website: ( click here ) About Crofelemer Crofelemer is the only oral FDA-approved prescription drug under botanical guidance. It is plant-based, extracted and purified from the red bark sap of the Croton lechleri tree in the Amazon Rainforest. Napo Pharmaceuticals, a Jaguar family company, has established a sustainable harvesting program, under fair trade practices, for crofelemer to ensure a high degree of quality, ecological integrity, and support for Indigenous communities. About the Jaguar Health Family of Companies Jaguar Health, Inc. (Jaguar) is a commercial stage pharmaceuticals company focused on developing novel proprietary prescription medicines sustainably derived from plants from rainforest areas for people and animals with gastrointestinal distress, specifically associated with overactive bowel, which includes symptoms such as chronic debilitating diarrhea, urgency, bowel incontinence, and cramping pain. Jaguar family company Napo Pharmaceuticals (Napo) focuses on developing and commercializing human prescription pharmaceuticals for essential supportive care and management of neglected gastrointestinal symptoms across multiple complicated disease states. Napo's crofelemer is FDA-approved under the brand name Mytesi ® for the symptomatic relief of noninfectious diarrhea in adults with HIV/AIDS on antiretroviral therapy. Jaguar family company Napo Therapeutics is an Italian corporation Jaguar established in Milan, Italy in 2021 focused on expanding crofelemer access in Europe and specifically for orphan diseases. Jaguar Animal Health is a Jaguar tradename. Magdalena Biosciences, a joint venture formed by Jaguar and Filament Health Corp. that emerged from Jaguar's Entheogen Therapeutics Initiative (ETI), is focused on developing novel prescription medicines derived from plants for mental health indications. For more information about: Jaguar Health, visit https://jaguar.health Napo Pharmaceuticals, visit www.napopharma.com Napo Therapeutics, visit napotherapeutics.com Magdalena Biosciences, visit magdalenabiosciences.com Canalevia-CA1, visit canalevia.com Visit the Make Cancer Less Shitty patient advocacy program on Bluesky , X , Facebook & Instagram About Mytesi ® Mytesi (crofelemer) is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Mytesi is not indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before starting Mytesi. If infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not receive the appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a rate greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and increased bilirubin (3.1%). See full Prescribing Information at Mytesi.com . Crofelemer, the active ingredient in Mytesi, is a botanical (plant-based) drug extracted and purified from the red bark sap of the medicinal Croton lechleri tree in the Amazon rainforest. Napo has established a sustainable harvesting program for crofelemer to ensure a high degree of quality and ecological integrity. About Gelclair ® INDICATIONS GELCLAIR ® has a mechanical action indicated for the management of pain and relief of pain by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies, including oral mucositis/stomatitis (may be caused by chemotherapy or radiation therapy), irritation due to oral surgery, traumatic ulcers caused by braces or ill-fitting dentures, or disease. Also, indicated for diffuse aphthous ulcers. IMPORTANT SAFETY INFORMATION Do not use GELCLAIR if there is a known or suspected hypersensitivity to any of its ingredients. No adverse effects have been reported in clinical trials, although postmarketing reports have included infrequent complaints of burning sensation in the mouth. If GELCLAIR is swallowed accidentally, no adverse effects are anticipated. If no improvement is seen within 7 days, a physician should be consulted. You are encouraged to report negative side effects of prescription medical products to the FDA. Visit www.fda.gov/safety/medwatch or call 1-855-273-0468. Please see full Prescribing Information at: https://www.gelclairhcp.com/pdf/prescribing-information-instructions-for-use.pdf Important Safety Information About Canalevia ® -CA1 For oral use in dogs only. Not for use in humans. Keep Canalevia-CA1 (crofelemer delayed-release tablets) in a secure location out of reach of children and other animals. Consult a physician in case of accidental ingestion by humans. Do not use in dogs that have a known hypersensitivity to crofelemer. Prior to using Canalevia-CA1, rule out infectious etiologies of diarrhea. Canalevia-CA1 is a conditionally approved drug indicated for the treatment of chemotherapy-induced diarrhea in dogs. The most common adverse reactions included decreased appetite, decreased activity, dehydration, abdominal pain, and vomiting. Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian. Use only as directed. It is a violation of Federal law to use this product other than as directed in the labeling. Conditionally approved by FDA pending a full demonstration of effectiveness under application number 141-552. See full Prescribing Information at Canalevia.com . Forward-Looking Statements Certain statements in this press release constitute "forward-looking statements." These include statements regarding Jaguar's expectation that it will hold an investor webcast on November 17, 2025, and Jaguar's expectation that crofelemer can potentially extend lives of MVID patients, reducing the volume of the PS necessary for them to survive. In some cases, you can identify forward-looking statements by terms such as "may," "will," "should," "expect," "plan," "aim," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "estimate," "predict," "potential" or "continue" or the negative of these terms or other similar expressions. The forward-looking statements in this release are only predictions. Jaguar has based these forward-looking statements largely on its current expectations and projections about future events. These forward-looking statements speak only as of the date of this release and are subject to several risks, uncertainties, and assumptions, some of which cannot be predicted or quantified and some of which are beyond Jaguar's control. Except as required by applicable law, Jaguar does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. Source: Jaguar Health, Inc. Contact: hello@jaguar.health Jaguar-JAGX SOURCE: Jaguar Health, Inc. View the original press release on ACCESS Newswire View Comments Terms and Privacy Policy Privacy Dashboard More Info
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  Publisher URL	https://finance.yahoo.com
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  Trust Flow Score	83
  Citation Flow Score	57

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