Title	Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight
ID	4765375
External ID	7360391526
Author	Ankit Nigam
Published Date	Dec. 4, 2024, 12:56 a.m.
Summary	Complement Inhibitors Market Complement inhibitors companies are Genentech, Ionis, Roche, AKARI Therapeutics, CARE Pharma, NovelMed Therapeutics, Omeros Corporation, and others. ALBANY, NY, UNITED S
Tags	None
URL	https://dental.einnews.com/pr_news/766027860/complement-inhibitors-market-2034-clinical-trials-medication-therapies-fda-approvals-companies-by-delveinsight
Sentiment	Negative: 0.00951 Neutral: 0.42889 Positive: 0.56160
Relevance	0.01282

Content ID	2863267
Key	0929093e-1a66-4700-b447-b9198a5c56da
Content	Complement Inhibitors Market Complement inhibitors companies are Genentech, Ionis, Roche, AKARI Therapeutics, CARE Pharma, NovelMed Therapeutics, Omeros Corporation, and others. ALBANY, NY, UNITED STATES, December 4, 2024 / EINPresswire.com / -- (Albany, USA) DelveInsight's Complement Inhibitors Market Insights report includes a comprehensive understanding of current treatment practices, emerging complement inhibitors, market share of individual therapies, and current and forecasted complement inhibitors market size from 2020 to 2034, segmented into 7MM [the United States, the EU-4 (Italy, Spain, France, and Germany), the United Kingdom, and Japan]. The market for complement inhibitors is expected to grow significantly in the coming years. Since the launch of SOLIRIS and ULTOMIRIS, the complement inhibitor market has seen a lot of traction, and many companies are now developing novel complement inhibitors, potentially paralleling the efficacy and safety profile of eculizumab. Key Takeaways from the Complement Inhibitors Market • As per DelveInsight's analysis, the current market size of complement inhibitors is estimated to be approximately USD 7 billion, in the 7MM in 2023. • Leading complement inhibitors companies such as Genentech, Ionis, Roche, AKARI Therapeutics, CARE Pharma, NovelMed Therapeutics, Omeros Corporation, and others are developing novel complement inhibitors that can be available in the complement inhibitors market in the coming years. • Some of the key complement inhibitors include Crovalimab, IONIS-FB-LRx/RG6299, Nomacopan, CAN-106, Ruxoprubart, OMS-906, and others. • In February 2024, the FDA granted an Orphan Drug Designation (ODD) to ruxoprubart for the treatment of PNH. Discover which therapies are expected to grab the complement inhibitors market share @ Complement Inhibitors Market Report Complement Inhibitors Market Dynamics The complement inhibitors market has been witnessing significant growth, driven by the increasing prevalence of autoimmune and inflammatory diseases. As research and development in immunology advance, the understanding of the complement system's role in various diseases has deepened, spurring interest in developing inhibitors to manage conditions like atypical hemolytic uremic syndrome (aHUS), paroxysmal nocturnal hemoglobinuria (PNH), and other complement-mediated disorders. One of the key market dynamics is the rising incidence of rare diseases that are driven by complement system dysregulation. Pharmaceutical companies are increasingly investing in this niche but growing segment, recognizing the potential for high-revenue treatments due to the high cost of rare disease drugs. For instance, therapies like eculizumab (SOLIRIS) and ravulizumab (ULTOMIRIS) have set a precedent in the market, demonstrating the commercial viability and life-saving potential of complement inhibitors. Additionally, the orphan drug designation granted to many complement inhibitors by regulatory authorities provides incentives such as market exclusivity, further fueling market growth. Technological advancements and innovations in biotechnology have also played a pivotal role in shaping the complement inhibitors market. The advent of monoclonal antibodies, recombinant proteins, and small molecule inhibitors has broadened the therapeutic arsenal available to clinicians. These advancements not only enhance the efficacy and specificity of treatments but also improve patient outcomes by reducing adverse effects associated with traditional therapies. Furthermore, ongoing clinical trials and pipeline products hold promise for expanding the indications of complement inhibitors, potentially addressing a wider range of diseases and patient populations. Market dynamics are also influenced by strategic collaborations, mergers, and acquisitions among key industry players. Pharmaceutical companies are keen on enhancing their product portfolios and accelerating the development of novel therapies through strategic alliances. Collaborations with academic institutions and research organizations are crucial for harnessing cutting-edge research and translating it into viable therapeutic options. Additionally, acquisitions of smaller biotech firms by larger pharmaceutical companies help consolidate market presence and drive innovation by pooling resources and expertise. Despite the promising outlook, the complement inhibitors market faces challenges such as high treatment costs and stringent regulatory frameworks. The high cost of complement inhibitor therapies can limit patient access and pose reimbursement challenges, particularly in developing regions. Moreover, the regulatory landscape demands rigorous clinical testing and evidence of efficacy and safety, which can prolong the drug development process and increase costs. However, ongoing efforts to streamline regulatory pathways and enhance market access, coupled with the growing awareness of complement-mediated diseases, are expected to mitigate some of these challenges and sustain market growth in the coming years. Complement Inhibitors Treatment Market There are many opportunities to pharmacologically block unwanted complement activation. For instance, complement inhibitors can be directed at the DAMP or PAMP recognition components of the complement system, specific activation pathways (such as LP, CL, and AP), the C3/C5 convertases, C3 or C5 itself, and their activation effector molecules or complexes (including C3a, C5a, their respective receptors, CR3, and the MAC). Complement inhibition has also shown some efficacy in treating C3-glomerulopathy (C3GN) (including dense deposit disease, DDD), antibody-mediated acute rejection of kidney transplants, severe antiphospholipid syndrome, vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA), myasthenia gravis, and neuromyelitis optica. The Complement Inhibitors market landscape includes C5, C3, Factor-B, and Factor-D inhibitors. Besides Alexion Pharmaceuticals/AstraZeneca's SOLIRIS and ULTOMIRIS, the market consists of major players, including but not limited to Novartis' FABHALTA (iptacopan), Apellis' pegcetacoplan, Astellas' IZERVAY, and UCBs' ZILBRYSQ (zilucoplan). VOYDEYA (danicopan) is a pioneering oral Factor D inhibitor. It functions by specifically targeting and inhibiting Factor D, a protein integral to the complement system, which is crucial in enhancing the complement system response. An uncontrolled activation of this cascade can cause the body to mistakenly attack its own healthy cells. Voydeya has received breakthrough therapy designation from the US FDA and PRIME status from the European Medicines Agency. Additionally, it has been granted orphan drug designation in the US, EU, and Japan for treating PNH. AstraZeneca/Alexion is also exploring the use of VOYDEYA as a standalone treatment for geographic atrophy in a Phase II clinical trial. Zilucoplan is a once-daily, subcutaneous, self-administered peptide that inhibits complement component 5 (C5). As the only once-daily therapy for generalized myasthenia gravis (gMG) that can be self-administered by adults with anti-AChR antibody-positive gMG, zilucoplan prevents complement-mediated damage to the neuromuscular junction through its specific mechanism. The FDA approved the drug in October 2023. Additionally, in September 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommended marketing authorization for zilucoplan in the European Union (EU) as an add-on to standard therapy for treating gMG. EMA granted this authorization in December 2023. In the same year, the Japanese Ministry of Health, Labour, and Welfare (MHLW) approved zilucoplan for treating gMG in adults who do not adequately respond to steroids or other immunosuppressants. Learn more about the FDA-approved complement inhibitors @ Complement Inhibitors Drugs Key Emerging Complement Inhibitors and Companies Several key players, including Genentech (Crovalimab), Ionis/Roche (IONIS-FB-LRx/RG6299), and others, are involved in developing complement inhibitors for various indications. Crovalimab is a new, investigational anti-C5 recycling monoclonal antibody aimed at inhibiting the complement system. By binding to C5, it blocks the final step of the complement cascade and is recycled within the bloodstream, allowing for rapid and sustained inhibition. Its recycling properties enable low-dose subcutaneous (SC) administration every four weeks. Crovalimab targets a different C5 binding site than current treatments, potentially benefiting those with specific C5 gene mutations who do not respond to existing therapies. It is also being studied for use in atypical hemolytic uremic syndrome, sickle cell disease, and other complement-mediated diseases. In September 2023, the FDA accepted the Biologics License Application (BLA) for crovalimab for treating paroxysmal nocturnal hemoglobinuria (PNH). If approved, it will be the first monthly subcutaneous treatment for PNH, allowing for self-administration outside a supervised healthcare setting. IONIS-FB-LRx, also known as RG6299, is an antisense oligonucleotide designed to suppress the expression of the complement factor B gene by binding to its mRNA. It is currently being investigated for the treatment of geographic atrophy and IgA nephropathy in a Phase II clinical trial. Other complement inhibitors in the pipeline include • Nomacopan: AKARI Therapeutics • CAN-106: CARE Pharma • Ruxoprubart: NovelMed Therapeutics • OMS-906: Omeros Corporation The anticipated launch of these emerging therapies are poised to transform the complement inhibitors market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the complement inhibitors market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth. To know more about complement inhibitors clinical trials, visit @ https://www.delveinsight.com/report-store/complement-inhibitors-c3-c5-competitive-market-forecast?utm_source=einpresswire&utm_medium=pressrelease&utm_campaign=apr Complement Inhibitors Overview The complement system is an essential part of the innate immune response, consisting of over 50 different plasma and serum proteins. These proteins work together to tag pathogens for destruction and trigger inflammatory responses to combat infections. Normally, the core components of the complement system, C3, and C5, are present in the bloodstream in inactive forms. They can be activated through three distinct pathways: the classical pathway, the lectin pathway, and the alternative pathway (AP). Each pathway is triggered by specific pathogen- or danger-associated molecular patterns (PAMPs and DAMPs), yet they converge on common processes, leading to the formation of C3 and C5 convertases and ultimately the pathogen-killing terminal pathway. Disorders such as atypical hemolytic uremic syndrome (aHUS), C3 glomerulopathy, and paroxysmal nocturnal hemoglobinuria are classic examples of complement system dysregulation. Moreover, the list of diseases where complement dysregulation is a confirmed pathological factor continues to grow. Complement Inhibitors Market Report Metrics • Study Period: 2020–2034 • Complement Inhibitors Report Coverage: 7MM [The United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan] • Complement Inhibitors Market Size in 2023: USD 7 Billion • Key Complement Inhibitors Companies: Genentech, Ionis, Roche, AKARI Therapeutics, CARE Pharma, NovelMed Therapeutics, Omeros Corporation, and others • Key Complement Inhibitors: Crovalimab, IONIS-FB-LRx/RG6299, Nomacopan, CAN-106, Ruxoprubart, OMS-906, and others Scope of the Complement Inhibitors Market Report • Complement Inhibitors Therapeutic Assessment: Complement Inhibitors current marketed and emerging therapies • Complement Inhibitors Market Dynamics: Conjoint Analysis of Emerging Complement Inhibitors Drugs • Competitive Intelligence Analysis: SWOT analysis and Market entry strategies • Unmet Needs, KOL's views, Analyst's views, Complement Inhibitors Market Access and Reimbursement Discover more about complement inhibitors in development @ Complement Inhibitors Clinical Trials and Advancements Table of Contents 1. Complement Inhibitors Market Key Insights 2. Complement Inhibitors Market Report Introduction 3. Complement Inhibitors Market Overview at a Glance 4. Complement Inhibitors Market Executive Summary 5. Disease Background and Overview 6. Complement Inhibitors Treatment and Management 7. Complement Inhibitors Epidemiology and Patient Population 8. Patient Journey 9. Complement Inhibitors Marketed Drugs 10. Complement Inhibitors Emerging Drugs 11. Seven Major Complement Inhibitors Market Analysis 12. Complement Inhibitors Market Outlook 13. Potential of Current and Emerging Therapies 14. KOL Views 15. Unmet Needs 16. SWOT Analysis 17. Appendix 18. DelveInsight Capabilities 19. Disclaimer 20. About DelveInsight About Us DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve. Trending Reports: • Concussions Market Size: https://www.delveinsight.com/report-store/concussions-market • Diffuse Large B-cell Lymphoma Market: https://www.delveinsight.com/report-store/diffuse-large-b-cell-lymphoma-market • Dyspnea Market: https://www.delveinsight.com/report-store/dyspnea-market • Hearing Implants Market: https://www.delveinsight.com/report-store/hearing-implants-market • Abetalipoproteinemia Market: https://www.delveinsight.com/report-store/abetalipoproteinemia-market Ankit Nigam DelveInsight Business Research email us here Visit us on social media: Facebook X LinkedIn Instagram YouTube
Content Reference URL	None

Publisher Name	Reddit
Publisher URL	https://www.einnews.com
Description	None
Trust Flow Score	15
Citation Flow Score	9

Data Source Name	Quantexa News
Data Source Type	news
Data Source URL	https://app.aylien.com/dashboard
Description	Welcome to Quantexa News API — the most powerful way to aggregate, filter, and integrate global news data into your apps and models.
Weight	10

DJDT

Versions

Package	Name	Version
Django		5.0.3
Python		3.11.8
coverage	Coverage	7.4.4
debug_toolbar	Debug Toolbar	4.3.0
django_extensions	Django Extensions	3.2.3
grappelli	Grappelli	3.0.8

Time

Resource usage

Resource	Value
User CPU time	69.912 msec
System CPU time	4.078 msec
Total CPU time	73.990 msec
Elapsed time	78.499 msec
Context switches	6 voluntary, 1 involuntary

Browser timing

Timing attribute	Timeline	Milliseconds since navigation start (+length)

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Headers

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Accept	/
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Response headers

Key	Value
Content-Type	text/html; charset=utf-8

WSGI environ

Since the WSGI environ inherits the environment of the server, only a significant subset is shown below.

Key	Value
CONTENT_LENGTH
CONTENT_TYPE
PATH_INFO	/ticker/OMER/content/4765375
QUERY_STRING
REMOTE_ADDR	18.222.179.192
REQUEST_METHOD	GET
SCRIPT_NAME
SERVER_NAME	pennyloupe.com
SERVER_PORT	443
SERVER_PROTOCOL	HTTP/1.1

Request

View information

View function	Arguments	Keyword arguments	URL name
`app.core.views.app.ticker_content_detail`	`()`	`{'content_id': 4765375, 'ticker': 'OMER'}`	`ticker_content_detail`

No cookies

No session data

No GET data

No POST data

SQL queries from 1 connection

default 4.74 ms (4 queries )

	Query		Timeline	Time (ms)	Action
		SELECT "pl_content"."created_dt", "pl_content"."updated_dt", "pl_content"."status_id", "pl_content"."id", "pl_content"."key", "pl_content"."fetch_ref_id", "pl_content"."ticker", "pl_content"."publish_dt", "pl_content"."external_id", "pl_content"."published_by", "pl_content"."title", "pl_content"."summary", "pl_content"."tags", "pl_content"."url", "pl_content"."author", "pl_content"."author_reputation_score", "pl_content"."content_length", "pl_content"."sentiment_positive", "pl_content"."sentiment_negative", "pl_content"."sentiment_neutral", "pl_content"."sentiment", "pl_content"."relevance_score", "pl_content"."votes_positive", "pl_content"."votes_negative", "pl_content"."is_processing_flag", "pl_content"."data_source_id", "pl_content"."publisher_id" FROM "pl_content" WHERE "pl_content"."id" = 4765375 LIMIT 21SELECT ••• FROM "pl_content" WHERE "pl_content"."id" = 4765375 LIMIT 21		1.03
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1405) content = Content.objects.get(id=content_id)
		SELECT "pl_content_content"."created_dt", "pl_content_content"."updated_dt", "pl_content_content"."status_id", "pl_content_content"."id", "pl_content_content"."key", "pl_content_content"."content", "pl_content_content"."content_ref_url", "pl_content_content"."content_id" FROM "pl_content_content" WHERE "pl_content_content"."content_id" = 4765375 ORDER BY "pl_content_content"."id" ASC LIMIT 1SELECT ••• FROM "pl_content_content" WHERE "pl_content_content"."content_id" = 4765375 ORDER BY "pl_content_content"."id" ASC LIMIT 1		2.08
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1411) content_content = ContentContent.objects.filter(details=content).first()
		SELECT "pl_content_publisher"."created_dt", "pl_content_publisher"."updated_dt", "pl_content_publisher"."status_id", "pl_content_publisher"."id", "pl_content_publisher"."name", "pl_content_publisher"."url", "pl_content_publisher"."domain", "pl_content_publisher"."description", "pl_content_publisher"."weight", "pl_content_publisher"."trust_flow_score", "pl_content_publisher"."citation_flow_score" FROM "pl_content_publisher" WHERE "pl_content_publisher"."id" = 351 LIMIT 21SELECT ••• FROM "pl_content_publisher" WHERE "pl_content_publisher"."id" = 351 LIMIT 21		0.82
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1414) publisher = content.publisher
		SELECT "pl_data_source"."created_dt", "pl_data_source"."updated_dt", "pl_data_source"."status_id", "pl_data_source"."id", "pl_data_source"."name", "pl_data_source"."type", "pl_data_source"."url", "pl_data_source"."description", "pl_data_source"."weight", "pl_data_source"."class_name", "pl_data_source"."class_params_json" FROM "pl_data_source" WHERE "pl_data_source"."id" = 5 LIMIT 21SELECT ••• FROM "pl_data_source" WHERE "pl_data_source"."id" = 5 LIMIT 21		0.81
		Connection: default Transaction status: Idle /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/whitenoise/middleware.py in __call__(124) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/django_htmx/middleware.py in __call__(43) return self.get_response(request) /mnt/disks/pennyloupe_disk/pennyloupe/app/core/views/app.py in ticker_content_detail(1415) data_source = content.data_source

Static files (717 found, 2 used)

Static file paths

None

Static file apps

grappelli
django.contrib.admin
django_htmx
app.core
django_extensions
debug_toolbar

Static files

css/pennyloupe.css: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/static/css/pennyloupe.css
img/penny_loupe_logo.png: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/static/img/penny_loupe_logo.png

django.contrib.staticfiles.finders.AppDirectoriesFinder (717 files)

Templates (6 rendered)

Template path

templates

Templates

ticker_content_detail.html: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/templates/ticker_content_detail.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653b86480>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653b868e0>>'} {'content_detail': {'content': <Content: Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight - Ankit Nigam>, 'content_content': <ContentContent: Content ID: 2863267>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Reddit>}, 'ticker': 'OMER'}
base.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/base.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653b86480>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653b868e0>>'} {'content_detail': {'content': <Content: Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight - Ankit Nigam>, 'content_content': <ContentContent: Content ID: 2863267>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Reddit>}, 'ticker': 'OMER'}
components/leftnav.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/leftnav.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653b86480>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653b868e0>>'} {'content_detail': {'content': <Content: Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight - Ankit Nigam>, 'content_content': <ContentContent: Content ID: 2863267>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Reddit>}, 'ticker': 'OMER'} {'block': <Block Node: leftnav. Contents: [<TextNode: '\n <div'>, <IncludeNode: template=<FilterExpression '"components/leftnav.html"'>>, <TextNode: '\n </di'>]>}
components/header.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/header.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653b86480>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653b868e0>>'} {'content_detail': {'content': <Content: Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight - Ankit Nigam>, 'content_content': <ContentContent: Content ID: 2863267>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Reddit>}, 'ticker': 'OMER'} {'block': <Block Node: header. Contents: [<TextNode: '\n\n '>, <IncludeNode: template=<FilterExpression '"components/header.html"'>>, <TextNode: '\n\n '>]>}
components/ticker_subnav.html: /mnt/disks/pennyloupe_disk/pennyloupe/app/core/templates/components/ticker_subnav.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653b86480>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653b868e0>>'} {'content_detail': {'content': <Content: Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight - Ankit Nigam>, 'content_content': <ContentContent: Content ID: 2863267>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Reddit>}, 'ticker': 'OMER'} {'block': <Block Node: content. Contents: [<TextNode: '\n\n <div class="uk-flex'>, <IncludeNode: template=<FilterExpression '"components/ticker_subnav.html"'>>, <TextNode: '\n <!-- /SUB NAV--'>, <Variable Node: content_detail.content.title>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.id>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.external_id>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.author>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.publish_dt>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.summary>, <TextNode: '</td>\n '>, <Variable Node: content_detail.content.tags>, <TextNode: '</td>\n '>, <IfNode>, <TextNode: '\n '>, <Variable Node: content_detail.content.sentiment_negative>, <TextNode: '   \n '>, <Variable Node: content_detail.content.sentiment_neutral>, <TextNode: '   \n '>, <Variable Node: content_detail.content.sentiment_positive>, <TextNode: '<br/>\n '>, <django.template.defaulttags.WidthRatioNode object at 0x7ff654269b10>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.sentiment_neutral>, <TextNode: '" style="width:'>, <django.template.defaulttags.WidthRatioNode object at 0x7ff654269f10>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.sentiment_positive>, <TextNode: '" style="width:'>, <django.template.defaulttags.WidthRatioNode object at 0x7ff65426a350>, <TextNode: '%;"></div>\n '>, <Variable Node: content_detail.content.relevance_score>, <TextNode: '</td>\n '>, <IfNode>, <TextNode: '\n '>, <IfNode>, <TextNode: '\n <li clas'>, <Variable Node: content_detail.data_source.name>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.type>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.url>, <TextNode: '" target="_blank">'>, <Variable Node: content_detail.data_source.url>, <TextNode: '</a></td>\n '>, <Variable Node: content_detail.data_source.description>, <TextNode: '</td>\n '>, <Variable Node: content_detail.data_source.weight>, <TextNode: '</td>\n '>]>} {'ticker': 'OMER'}
components/footer.html: /mnt/disks/pennyloupe_disk/pennyloupe/templates/components/footer.html; Toggle context
{'False': False, 'None': None, 'True': True} {'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'ERROR': 40, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30}, 'csrf_token': '<SimpleLazyObject: <function csrf.<locals>._get_val at ' '0x7ff653b86480>>', 'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>), 'request': '<<request>>', 'user': '<SimpleLazyObject: <function ' 'AuthenticationMiddleware.process_request.<locals>.<lambda> at ' '0x7ff653b868e0>>'} {'content_detail': {'content': <Content: Complement Inhibitors Market 2034: Clinical Trials, Medication, Therapies, FDA Approvals, Companies by DelveInsight - Ankit Nigam>, 'content_content': <ContentContent: Content ID: 2863267>, 'data_source': <DataSource: Quantexa News>, 'publisher': <ContentPublisher: Reddit>}, 'ticker': 'OMER'} {'block': <Block Node: footer. Contents: [<TextNode: '\n '>, <IncludeNode: template=<FilterExpression '"components/footer.html"'>>, <TextNode: '\n '>]>}

Context processors

django.template.context_processors.csrf: Toggle context
{'csrf_token': <SimpleLazyObject: <function csrf.<locals>._get_val at 0x7ff653b86480>>}
django.template.context_processors.debug: Toggle context
{}
django.template.context_processors.request: Toggle context
{'request': <WSGIRequest: GET '/ticker/OMER/content/4765375'>}
django.contrib.auth.context_processors.auth: Toggle context
{'user': <SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>, 'perms': PermWrapper(<SimpleLazyObject: <function AuthenticationMiddleware.process_request.<locals>.<lambda> at 0x7ff653b868e0>>)}
django.contrib.messages.context_processors.messages: Toggle context
{'messages': <FallbackStorage: request=<WSGIRequest: GET '/ticker/OMER/content/4765375'>>, 'DEFAULT_MESSAGE_LEVELS': {'DEBUG': 10, 'INFO': 20, 'SUCCESS': 25, 'WARNING': 30, 'ERROR': 40}}

Cache calls from 1 backend

Summary

Total calls	Total time	Cache hits	Cache misses
0	0 ms	0	0

Commands

add	get	set	get_or_set	touch	delete	clear	get_many	set_many	delete_many	has_key	incr	decr	incr_version	decr_version
0	0	0	0	0	0	0	0	0	0	0	0	0	0	0

Signals

Signal	Receivers
class_prepared
connection_created	register_type_handlers
got_request_exception
m2m_changed
post_delete
post_init
post_migrate	create_permissions, create_contenttypes
post_save	create_initial_trade_position
pre_delete
pre_init
pre_migrate	inject_rename_contenttypes_operations
pre_save
request_finished	close_old_connections, close_caches, reset_urlconf
request_started	reset_queries, close_old_connections
setting_changed	reset_cache, clear_cache_handlers, update_installed_apps, update_connections_time_zone, clear_routers_cache, reset_template_engines, storages_changed, clear_serializers_cache, language_changed, localize_settings_changed, file_storage_changed, complex_setting_changed, root_urlconf_changed, static_storage_changed, static_finders_changed, auth_password_validators_changed, user_model_swapped, update_toolbar_config, reset_hashers, update_level_tags, uninstall_if_needed, clear_caches, StaticFilesStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties, FileSystemStorage._clear_cached_properties

Path	Location
.DS_Store	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/.DS_Store
grappelli/.DS_Store	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/.DS_Store
grappelli/js/grappelli.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/grappelli.js
grappelli/js/jquery.grp_related_m2m.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_m2m.js
grappelli/js/jquery.grp_autocomplete_fk.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_fk.js
grappelli/js/jquery.grp_autocomplete_generic.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_generic.js
grappelli/js/jquery.grp_timepicker.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_timepicker.js
grappelli/js/jquery.grp_collapsible_group.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_collapsible_group.js
grappelli/js/jquery.grp_related_generic.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_generic.js
grappelli/js/jquery.grp_related_fk.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_related_fk.js
grappelli/js/jquery.grp_collapsible.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_collapsible.js
grappelli/js/grappelli.min.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/grappelli.min.js
grappelli/js/jquery.grp_autocomplete_m2m.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_autocomplete_m2m.js
grappelli/js/jquery.grp_inline.js	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/js/jquery.grp_inline.js
grappelli/images/spritesheet-1694777276.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/spritesheet-1694777276.png
grappelli/images/backgrounds/loading-small.gif	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/loading-small.gif
grappelli/images/backgrounds/changelist-results.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/changelist-results.png
grappelli/images/backgrounds/ui-sortable-placeholder.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/ui-sortable-placeholder.png
grappelli/images/backgrounds/nav-grabber.gif	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/nav-grabber.gif
grappelli/images/backgrounds/messagelist.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/backgrounds/messagelist.png
grappelli/images/icons/ui-datepicker-next.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/ui-datepicker-next.png
grappelli/images/icons/link-external-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/link-external-small_hover.png
grappelli/images/icons/tools-arrow-up-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-arrow-up-handler_hover.png
grappelli/images/icons/date-hierarchy-back.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/date-hierarchy-back.png
grappelli/images/icons/tools-delete-handler-predelete.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-delete-handler-predelete.png
grappelli/images/icons/breadcrumbs-rtl.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/breadcrumbs-rtl.png
grappelli/images/icons/datepicker_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/datepicker_hover.png
grappelli/images/icons/tools-trash-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-trash-handler_hover.png
grappelli/images/icons/selector-add-m2m-vertical_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/selector-add-m2m-vertical_hover.png
grappelli/images/icons/tools-related-remove-handler-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-remove-handler-small_hover.png
grappelli/images/icons/sorted-descending.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/sorted-descending.png
grappelli/images/icons/breadcrumbs_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/breadcrumbs_hover.png
grappelli/images/icons/tools-viewsite-link_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-viewsite-link_hover.png
grappelli/images/icons/object-tools-add-link.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/object-tools-add-link.png
grappelli/images/icons/tools-related-edit-handler-small-disabled.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-edit-handler-small-disabled.png
grappelli/images/icons/tools-related-remove-handler-small-disabled.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-related-remove-handler-small-disabled.png
grappelli/images/icons/sorted-ascending.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/sorted-ascending.png
grappelli/images/icons/link-internal-rtl-small_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/link-internal-rtl-small_hover.png
grappelli/images/icons/pulldown-handler_selected.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/pulldown-handler_selected.png
grappelli/images/icons/tools-delete-handler_hover.png	/mnt/disks/pennyloupe_disk/pennyloupe/.venv/lib/python3.11/site-packages/grappelli/static/grappelli/images/icons/tools-delete-handler_hover.png

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